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Effects of Three Calcium Silicate Cements on Inflammatory Response and Mineralization-Inducing Potentials in a Dog Pulpotomy Model
- Source :
- Materials, Vol 11, Iss 6, p 899 (2018), Materials; Volume 11; Issue 6; Pages: 899, Materials
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- This beagle pulpotomy study compared the inflammatory response and mineralization-inducing potential of three calcium silicate cements: ProRoot mineral trioxide aggregate (MTA) (Dentsply, Tulsa, OK, USA), OrthoMTA (BioMTA, Seoul, Korea), and Endocem MTA (Maruchi, Wonju, Korea). Exposed pulp tissues were capped with ProRoot MTA, OrthoMTA, or Endocem MTA. After 8 weeks, we extracted the teeth, then performed hematoxylin-eosin and immunohistochemical staining with osteocalcin and dentin sialoprotein. Histological evaluation comprised a scoring system with eight broad categories and analysis of calcific barrier areas. We evaluated 44 teeth capped with ProRoot MTA (n = 15), OrthoMTA (n = 18), or Endocem MTA (n = 11). Most ProRoot MTA specimens formed continuous calcific barriers; these pulps contained inflammation-free palisading patterns in the odontoblastic layer. Areas of the newly formed calcific barrier were greater with ProRoot MTA than with Endocem MTA (p = 0.006). Although dentin sialoprotein was highly expressed in all three groups, the osteocalcin expression was reduced in the OrthoMTA and Endocem MTA groups. ProRoot MTA was superior to OrthoMTA and Endocem MTA in all histological analyses. ProRoot MTA and OrthoMTA resulted in reduced pulpal inflammation and more complete calcific barrier formation, whereas Endocem MTA caused a lower level of calcific barrier continuity with tunnel defects.
- Subjects :
- 0301 basic medicine
Mineral trioxide aggregate
calcium silicate cements
pulpal response
mineralization
calcific barrier
inflammation
odontoblastic layer
Inflammatory response
Pulpotomy
Dentistry
lcsh:Technology
Mineralization (biology)
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
stomatognathic system
General Materials Science
lcsh:Microscopy
lcsh:QC120-168.85
lcsh:QH201-278.5
biology
lcsh:T
business.industry
030206 dentistry
030104 developmental biology
chemistry
lcsh:TA1-2040
Calcium silicate
Osteocalcin
biology.protein
Pulp (tooth)
lcsh:Descriptive and experimental mechanics
lcsh:Electrical engineering. Electronics. Nuclear engineering
lcsh:Engineering (General). Civil engineering (General)
business
lcsh:TK1-9971
Dentin sialoprotein
Subjects
Details
- ISSN :
- 19961944
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Materials
- Accession number :
- edsair.doi.dedup.....49b0c489d86a57b18bf34c286a4bd1d3
- Full Text :
- https://doi.org/10.3390/ma11060899