Journal of Periodontology

p. 683-688 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-01T11:39:09Z No. of bitstreams: 1 Patricia R. Cury.pdf: 515168 bytes, checksum: 88fef89bc44f574506e133c1bf50fa6b (MD5) Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-10-07T14:48:14Z (GMT) No. of bitstreams: 1 Patricia R. Cury.pdf: 515168 bytes, checksum: 88fef89bc44f574506e133c1bf50fa6b (MD5) Made available in DSpace on 2014-10-07T14:48:14Z (GMT). No. of bitstreams: 1 Patricia R. Cury.pdf: 515168 bytes, checksum: 88fef89bc44f574506e133c1bf50fa6b (MD5) Previous issue date: 2011 Background: This pilot study evaluates the association of severe periodontitis with pulse wave velocity (PWV), carotid artery intima-medial thickness (IMT), and clinical, metabolic, and atherogenic inflammatory markers in 79 subjects with heterozygous familial hypercholesterolemia (hFH). All subjects were free of previous vascular disease manifestations. Methods: The body mass index (in kilograms per square meter), plasma lipids, glucose, C-reactive protein, and white blood cell counts were evaluated. After full-mouth periodontal examinations, patients were categorized into the severe periodontitis group (SPG) or non-severe periodontitis group (NSPG). Results: The SPG showed significantly higher values of cholesterol-year scores, triglycerides, glucose, PWV, IMT, and diastolic blood pressure (DBP) (P ≤0.05) than the NSPG. After adjustment for traditional risk factors for atherosclerosis, only the association between severe periodontitis and DBP (odds ratio: 3.1; 95% CI: 1.1 to 8.5; P = 0.03) was confirmed. Conclusion: In individuals with hFH, severe periodontitis was associated with a higher DBP, which suggests that severe periodontitis, itself, may contribute to the increased cardiovascular risk profile in this population.