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A systematic investigation of the association between HPV and the clinicopathological parameters and prognosis of oral and oropharyngeal squamous cell carcinomas
- Source :
- Cancer Medicine
- Publication Year :
- 2016
-
Abstract
- Human papillomavirus (HPV), the causal factor of cervical cancers, was closely linked to the etiology and prognosis of oropharyngeal squamous cell carcinoma (OPSCC), but its role in oral squamous cell carcinoma (OSCC) was unclear. In addition, few researches based on Chinese population were documented. Hence, we sought to investigate the relationship of HPV marker P16 protein to the clinicopathological parameters and survival of OPSCC and OSCC patients systematically to assess the influence of ethnic, regional difference on HPV susceptibility. Specimens from 93 OPSCC patients and 95 OSCC patients were recut, and P16 immunohistochemistry (IHC) was performed. Moreover, survival analysis was conducted to confirm the independent factors that influenced the prognosis. The P16 results were positive in 25.8% and 9.5% of patients with OPSCC and OSCC, respectively. The overall survival (OS) of HPV‐positive OPSCC patients was significantly longer than that of HPV‐negative OPSCC patients (P = 0.004). Conversely, statistical significance was not observed regarding the OS of OSCC patients (P = 0.343). Cox regression analysis indicated that T stage and P16 status were independent factors that affected the prognosis of OPSCC patients, and the smoking index influenced the prognosis of OSCC patients. Among OPSCC patients who received radiochemotherapy (RCT), HPV‐positive patients had a better survival rate than their HPV‐negative counterparts (P = 0.015). Conversely, no significant difference was observed between HPV‐positive and HPV‐negative OSCC patients who received RCT (P = 0.237). P16 is a credible surrogate by which to define HPV status. HPV expression had a favorable effect on OPSCC patients as opposed to their OSCC counterparts in this single center population‐based study.
- Subjects :
- 0301 basic medicine
Oncology
Male
Cancer Research
medicine.medical_specialty
Human papillomavirus
Population
Single Center
03 medical and health sciences
Viral Proteins
0302 clinical medicine
Risk Factors
Internal medicine
Statistical significance
medicine
Humans
Radiology, Nuclear Medicine and imaging
education
Survival rate
Survival analysis
Neoplasm Staging
Original Research
education.field_of_study
Human papillomavirus 16
Proportional hazards model
business.industry
Squamous Cell Carcinoma of Head and Neck
Papillomavirus Infections
Clinical Cancer Research
P16
Middle Aged
Prognosis
Survival Analysis
Survival Rate
oral squamous cell carcinoma
stomatognathic diseases
Oropharyngeal Neoplasms
030104 developmental biology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
immunohistochemistry
Etiology
Carcinoma, Squamous Cell
oropharyngeal squamous cell carcinoma
T-stage
Female
Mouth Neoplasms
business
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 6
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cancer medicine
- Accession number :
- edsair.doi.dedup.....49d0af6442b32c57701455587df14ccd