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Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes
- Source :
- Oxidative Medicine and Cellular Longevity, Vol 2018 (2018), Oxidative Medicine and Cellular Longevity
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- Paraoxonase-1 (PON1) and lipoprotein phospholipase A2 (Lp-PLA2) may exert an important protective role by preventing the oxidative transformation of high- and low-density lipoproteins (HDL and LDL, respectively). The activity of both enzymes is influenced by lipidome and proteome of the lipoprotein carriers. T2DM typically presents significant changes in the molecular composition of the lipoprotein subclasses. Thus, it becomes relevant to understand the interaction of PON1 and Lp-PLA2 with the subspecies of HDL, LDL, and other lipoproteins in T2DM. Serum levels of PON1-arylesterase and PON1-lactonase and Lp-PLA2 activities and lipoprotein subclasses were measured in 202 nondiabetic subjects (controls) and 92 T2DM outpatients. Arylesterase, but not lactonase or Lp-PLA2 activities, was inversely associated with TD2M after adjusting for potential confounding factors such as age, sex, smoking, body mass index, hypertension, and lipoprotein subclasses (odds ratio = 3.389, 95% confidence interval 1.069–14.756). Marked difference between controls and T2DM subjects emerged from the analyses of the associations of the three enzyme activities and lipoprotein subclasses. Arylesterase was independently related with large HDL-C and small intermediate-density lipoprotein cholesterol (IDL-C) in controls while, along with lactonase, it was related with small low-density lipoprotein cholesterol LDL-C, all IDL-C subspecies, and very low-density lipoprotein cholesterol (VLDL-C) in T2DM (p<0.05for all). Concerning Lp-PLA2, there were significant relationships with small LDL-C, large IDL-C, and VLDL-C only among T2DM subjects. Our study showed that T2DM subjects have lower levels of PON1-arylesterase compared to controls and that T2DM occurrence may coincide with a shift of PON1 and Lp-PLA2 towards the more proatherogenic lipoprotein subclasses. The possibility of a link between the two observed phenomena requires further investigations.
- Subjects :
- Male
0301 basic medicine
Aging
medicine.medical_specialty
Article Subject
Lipoproteins
Type 2 diabetes
030204 cardiovascular system & hematology
Biochemistry
Arylesterase
03 medical and health sciences
Economica
0302 clinical medicine
Internal medicine
Diabetes mellitus
Diabetes Mellitus
medicine
Humans
lcsh:QH573-671
Aged
1-Alkyl-2-acetylglycerophosphocholine Esterase, Aged, Aryldialkylphosphatase, Case-Control Studies, Diabetes Mellitus, Type 2, Female, Humans, Lipoproteins, Male, Middle Aged
biology
lcsh:Cytology
Aryldialkylphosphatase
business.industry
Case-control study
Paraoxonase
nutritional and metabolic diseases
Cell Biology
General Medicine
Middle Aged
medicine.disease
PON1
030104 developmental biology
Endocrinology
Diabetes Mellitus, Type 2
Case-Control Studies
1-Alkyl-2-acetylglycerophosphocholine Esterase
biology.protein
Female
lipids (amino acids, peptides, and proteins)
business
Body mass index
Type 2
Research Article
Lipoprotein
Subjects
Details
- ISSN :
- 19420994 and 19420900
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....49e6d2a6c8af07ec189915447f0e4c9c