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NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings
- Source :
- Cellular and Molecular Gastroenterology and Hepatology, Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 831-839 (2021)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Synopsis We studied the pathological consequence of long-term hypercholanemia caused by NTCP deficiency, and found that NTCP deficiency leads to gallbladder abnormalities in both mice and humans, thereby pointing to a potentially underappreciated cause for gallbladder diseases encountered by physicians in the clinic.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Steroid Metabolism, Inborn Errors
UPLC, ultrahigh-performance liquid chromatography
Adolescent
Gallbladder disease
Organic Anion Transporters, Sodium-Dependent
Gallstones
digestive system
Gastroenterology
Polymorphism, Single Nucleotide
03 medical and health sciences
Mice
0302 clinical medicine
Species Specificity
Internal medicine
MCA, muricholic acid
medicine
Animals
Humans
lcsh:RC799-869
Pathological
TBA, total bile acids
Original Research
Retrospective Studies
Mice, Knockout
Hepatology
Symporters
business.industry
Gallbladder
Infant
Cholic Acids
medicine.disease
NTCP, sodium taurocholate co-transporting polypeptide
WT, wild-type
FGF, fibroblast growth factor
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
BA, bile acid
030211 gastroenterology & hepatology
lcsh:Diseases of the digestive system. Gastroenterology
Female
LC-MS/MS, liquid chromatography with tandem mass spectrometry
business
Subjects
Details
- Language :
- English
- ISSN :
- 2352345X
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cellular and Molecular Gastroenterology and Hepatology
- Accession number :
- edsair.doi.dedup.....4a0911774b1f4677cc366058eab2158c