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Walnut oil improves spatial memory in rats and increases the expression of acid‐sensing ion channel genes Asic2a and Asic4
- Source :
- Food Science & Nutrition, Food Science & Nutrition, 7(1):293-301
- Publication Year :
- 2018
- Publisher :
- John Wiley and Sons Inc., 2018.
-
Abstract
- Although Walnut oil (WO) has been reported to enhance cognitive function, the underlying molecular mechanisms are not well understood. This study was designed to assess the effects of WO on spatial memory in rats through modulation of the expression of acid‐sensing ion channel genes, Asic2a and Asic4. To investigate the effect of WO on cognitive performance, we supplemented the diet of female rats with WO. The results showed that supplementation with WO at doses of 2.2 and 11 g kg−1 day−1 significantly improved learning and memory. In vitro treatment of rat hippocampal neuronal cells with appropriate doses of WO revealed a significant increase in the expression of Asic2a and Asic4 in a dose‐dependent manner at both the mRNA and protein levels. We conclude that WO intake might help to prevent cognitive decline, particularly in the elderly, and that ASIC genes in neurons can be the targets of compounds contained in the oil.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Morris water navigation task
Hippocampal formation
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
morris water maze
Cognitive decline
Ion channel
Acid-sensing ion channel
Original Research
acid‐sensing ion channels
Messenger RNA
Chemistry
Asic4
Walnut oil
Asic2a
In vitro
030104 developmental biology
Endocrinology
walnut oil
methylation
acid-sensing ion channels
030217 neurology & neurosurgery
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20487177
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Food Science & Nutrition
- Accession number :
- edsair.doi.dedup.....4a2679994e942dc38aab9292491c2810