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Parkinson’s disease pathogenesis from the viewpoint of small fish models
- Source :
- Journal of Neural Transmission. 125:25-33
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Parkinson's disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have recently been employed as a new model for Parkinson disease. In this review, we summarize fish models of Parkinson's disease mainly using our own findings and explain two major hypotheses of PD: lysosome dysfunction theory and mitochondrial dysfunction theory. Finally, we discuss the potential for future application of small fish model.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Neurology
Parkinson's disease
Oryzias
Disease
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Parkinsonian Disorders
Lysosome
medicine
Animals
Humans
Zebrafish
Biological Psychiatry
biology
Dopaminergic Neurons
Dopaminergic
Parkinson Disease
biology.organism_classification
medicine.disease
Mitochondria
Disease Models, Animal
Psychiatry and Mental health
030104 developmental biology
medicine.anatomical_structure
Fish
Neurology (clinical)
Lysosomes
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14351463 and 03009564
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Journal of Neural Transmission
- Accession number :
- edsair.doi.dedup.....4a28948b20d99bd964dde99e05aaf4dd