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Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders
- Source :
- Lester, K J, Roberts, S, Keers, R, Coleman, J R I, Breen, G, Wong, C C Y, Xu, X, Arendt, K, Blatter-Meunier, J, Bögels, S, Cooper, P, Creswell, C, Heiervang, E R, Herren, C, Hogendoorn, S M, Hudson, J L, Krause, K, Lyneham, H J, McKinnon, A, Morris, T, Nauta, M H, Rapee, R M, Rey, Y, Schneider, S, Schneider, S C, Silverman, W K, Smith, P, Thastum, M, Thirlwall, K, Waite, P, Wergeland, G J & Eley, T C 2016, ' Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders ', British Journal of Psychiatry, vol. 208, no. 2, pp. 182-188 . https://doi.org/10.1192/bjp.bp.114.154997, Lester, K, Roberts, S, Keers, R, Coleman, J, Breen, G, Wong, C, Xu, X, Arendt, K, Blatter-Meunier, J, Bögels, S, Cooper, P, Creswell, C, Heiervang, E, Herren, C, Hogendoorn, S, Hudson, J, Krause, K, Lyneham, H, McKinnon, A, Morris, T, Nauta, M, Rapee, R, Rey, Y, Schneider, S, Schneider, S, Silverman, W, Smith, P, Thastum, M, Thirlwall, K, Waite, P, Wergeland, G J & Eley, T 2015, ' Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders ', British Journal of Psychiatry . https://doi.org/10.1192/bjp.bp.114.154997, British Journal of Psychiatry, 208(2), 182-188. Royal College of Psychiatrists, The British Journal of Psychiatry, British journal of psychiatry, 208(2), 182-188. Royal College of Psychiatrists, The British Journal of Psychiatry, 208(2), 182-188. Cambridge University Press
- Publication Year :
- 2016
-
Abstract
- BackgroundWe previously reported an association between 5HTTLPR genotype and outcome following cognitive–behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome.AimsTo replicate the association between 5HTTLPR and CBT outcome in child anxiety from the Genes for Treatment study (GxT Cohort 2, n = 829).MethodLogistic and linear mixed effects models were used to examine the relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both cohorts were performed.ResultsThere was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2. Mega-analyses identified a significant association between 5HTTLPR and remission from all anxiety disorders at follow-up (odds ratio 0.45, P = 0.014), but not primary anxiety disorder outcomes.ConclusionsThe association between 5HTTLPR genotype and CBT outcome did not replicate. Short-allele homozygotes showed more positive treatment outcomes, but with small, non-significant effects. Future studies would benefit from utilising whole genome approaches and large, homogenous samples.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Genotype
medicine.medical_treatment
CBT
Anxiety
Treatment response
03 medical and health sciences
0302 clinical medicine
mental disorders
medicine
Genetics
Humans
Child
Psychiatry
Alleles
Psychiatric Status Rating Scales
Serotonin Plasma Membrane Transport Proteins
Cognitive Behavioral Therapy
business.industry
Remission Induction
Odds ratio
medicine.disease
Anxiety Disorders
3. Good health
030227 psychiatry
Clinical trial
Cognitive behavioral therapy
Psychiatry and Mental health
Treatment Outcome
Child, Preschool
Papers
Cohort
Cognitive therapy
Female
Gene-Environment Interaction
Therapygenetics
medicine.symptom
Attribution
business
030217 neurology & neurosurgery
Anxiety disorder
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 00071250 and 14721465
- Volume :
- 208
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- British Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....4a2b7e9e3639d82a179940cdcddb958d