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Anterior Leaflet Laceration to Prevent Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement
- Source :
- Journal of the American College of Cardiology. 73:2521-2534
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- BACKGROUND: Left ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) is a transcatheter mimic of surgical chord-sparing leaflet resection. OBJECTIVES: The purpose of this prospective multicenter trial was to study LAMPOON with transseptal (Edwards Lifesciences, Irvine, California) TMVR in annuloplasty rings or native mitral annular calcification (MAC). METHODS: Subjects at high or extreme surgical risk and prohibitive risk of LVOT obstruction from TMVR were included. Eligibility was modified midtrial to exclude subjects with threatened LVOT obstruction from a Sapien 3 valve fabric skirt. The primary endpoint was procedure survival with successful LAMPOON, with successful TMVR, without reintervention, and with LVOT gradient
- Subjects :
- Male
Cardiac Catheterization
Mitral annular calcification
medicine.medical_specialty
medicine.medical_treatment
Electrosurgery
Heart Valve Diseases
Ventricular outflow tract obstruction
030204 cardiovascular system & hematology
Lacerations
Article
Ventricular Outflow Obstruction
Intraoperative Period
03 medical and health sciences
0302 clinical medicine
Mitral valve
Multicenter trial
Heart Septum
Humans
Medicine
Ventricular outflow tract
In patient
Prospective Studies
030212 general & internal medicine
Aged
Aged, 80 and over
Heart Valve Prosthesis Implantation
Anterior leaflet
business.industry
Mitral valve replacement
Middle Aged
Surgery
Treatment Outcome
medicine.anatomical_structure
cardiovascular system
Mitral Valve
Female
medicine.symptom
Tomography, X-Ray Computed
Cardiology and Cardiovascular Medicine
business
Echocardiography, Transesophageal
Follow-Up Studies
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....4a2bd50982056c317429cb1ca1223709