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Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl4-Induced Hepatic Damage
- Source :
- Molecules; Volume 16; Issue 10; Pages: 8684-8693, Molecules, Vol 16, Iss 10, Pp 8684-8693 (2011), Molecules
- Publication Year :
- 2011
- Publisher :
- Molecular Diversity Preservation International, 2011.
-
Abstract
- In the present study the capacity of Radix Paeoniae Rubra aqueous extract (RPRAE) as an antioxidant to protect against carbon tetrachloride (CCl(4))-induced oxidative stress and hepatotoxicity in Wistar rats was investigated. Six groups of rats were used. Radix Paeoniae Rubra aqueous extract (100 or 200 or 300 mg/kg of bw) or bifendate (100 mg/kg of bw) were given daily by gavage to the animals on 28 consecutive days to elucidate the protective effects against CCl(4)-induced hepatotoxicity. The 20% CCl(4)/olive oil was gavage of gastric tube twice a week (on the third and seventh days of each week). The animals of normal control group were given only vehicle. The animals of CCl(4)-treated group were administered with CCl(4) twice a week (on the third and seventh days of each week) and with vehicle on rest of the days. The test materials were found effective as hepatoprotective agents, as evidenced by plasma and liver biochemical parameters. Therefore, the results of this study show that Radix Paeoniae Rubra aqueous extract can protect the liver against CCl(4)-induced oxidative damage in rats, and the hepatoprotective effects might be correlated with its antioxidant and free radical scavenger effects.
- Subjects :
- Male
Antioxidant
antioxidant
medicine.medical_treatment
Radix Paeoniae Rubra
Pharmaceutical Science
CCL4
Paeonia
Protective Agents
medicine.disease_cause
Plant Roots
digestive system
Antioxidants
Article
Analytical Chemistry
law.invention
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
law
Drug Discovery
medicine
Animals
hepatoprotection
rat
Rats, Wistar
Physical and Theoretical Chemistry
Hepatoprotective Agent
Traditional medicine
Carbon Tetrachloride Poisoning
Biphenyl Compounds
digestive, oral, and skin physiology
Organic Chemistry
carbon tetrachloride
Free radical scavenger
Rats
Oxidative Stress
Liver
Hepatoprotection
chemistry
Chemistry (miscellaneous)
Carbon tetrachloride
Molecular Medicine
Chemical and Drug Induced Liver Injury
Phytotherapy
Oxidative stress
Drugs, Chinese Herbal
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules; Volume 16; Issue 10; Pages: 8684-8693
- Accession number :
- edsair.doi.dedup.....4a2d42ce54a4baf1fe3846be7869e3fa
- Full Text :
- https://doi.org/10.3390/molecules16108684