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Right ventricular outflow tract velocity time integral-to-pulmonary artery systolic pressure ratio: a non-invasive metric of pulmonary arterial compliance differs across the spectrum of pulmonary hypertension

Authors :
Jonathan Menachem
Edo Y. Birati
Sula Mazimba
Steven M. Kawut
E. Wilson Grandin
Jeremy A. Mazurek
Gregory S. Troutman
Monique S. Tanna
Payman Zamani
Priyanka Bhattacharya
Anjali Vaidya
Julio A. Chirinos
Frances Mao
Paul R. Forfia
Kerri Akaya Smith
Arieh L. Fox
Source :
Pulmonary Circulation, Vol 9 (2019), Pulmonary Circulation
Publication Year :
2019
Publisher :
SAGE Publishing, 2019.

Abstract

Pulmonary arterial compliance (PAC), invasively assessed by the ratio of stroke volume to pulmonary arterial (PA) pulse pressure, is a sensitive marker of right ventricular (RV)-PA coupling that differs across the spectrum of pulmonary hypertension (PH) and is predictive of outcomes. We assessed whether the echocardiographically derived ratio of RV outflow tract velocity time integral to PA systolic pressure (RVOT-VTI/PASP) (a) correlates with invasive PAC, (b) discriminates heart failure with preserved ejection-associated PH (HFpEF-PH) from pulmonary arterial hypertension (PAH), and (c) is associated with functional capacity. We performed a retrospective cohort study of patients with PAH (n = 70) and HFpEF-PH (n = 86), which was further dichotomized by diastolic pressure gradient (DPG) into isolated post-capillary PH (DPG

Details

Language :
English
ISSN :
20458940
Volume :
9
Database :
OpenAIRE
Journal :
Pulmonary Circulation
Accession number :
edsair.doi.dedup.....4a3573a60c49c4f7755a42badefd97d0