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Progression of axial spondyloarthritis
- Source :
- Современная ревматология, Vol 15, Iss 3, Pp 7-14 (2021)
- Publication Year :
- 2021
- Publisher :
- IMA-PRESS LLC, 2021.
-
Abstract
- The spectrum of bone lesions in axial spondyloarthritis is of great interest. With inflammation and mechanical influence concurrence in the background, both tissue gain and tissue loss in a particular bone area can occur simultaneously. Moreover, if vertebral bone mass loss, perhaps, can be easily explained by chronic systemic inflammation, the reason of its gain, observed in axial spondyloarthritis remains a mystery. It is unclear whether it is a consequence of enhanced recovery processes after injury, adaptation to altered mechanical stress, response to inflammatory cells activation or cytokines, produced by them, or changes in Wnt signaling pathways (for example). Whether these factors act individually or collectively is also unclear.
- Subjects :
- 0301 basic medicine
Immunology
Inflammation
Systemic inflammation
03 medical and health sciences
0302 clinical medicine
Rheumatology
bone formation, bone gain
ankylosing spondylitis
medicine
Immunology and Allergy
Pharmacology (medical)
Axial spondyloarthritis
Vertebral bone
030203 arthritis & rheumatology
Ankylosing spondylitis
business.industry
Wnt signaling pathway
biomarkers
axial spondyloarthritis
Bone area
medicine.disease
030104 developmental biology
Bone lesion
Medicine
progression
medicine.symptom
business
Neuroscience
Subjects
Details
- Language :
- Russian
- ISSN :
- 19967012
- Volume :
- 15
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Современная ревматология
- Accession number :
- edsair.doi.dedup.....4a3849d678ecc6efe0ca844d6a742a8a