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Metabolic and endocrine connections of 17-hydroxypregnenolone in polycystic ovary syndrome women
- Source :
- Endocrine Connections, Endocrine Connections, Vol 6, Iss 7, Pp 479-488 (2017)
- Publication Year :
- 2017
- Publisher :
- Bioscientifica, 2017.
-
Abstract
- Objective To examine the anthropometric, and metabolic connections of 17-hydroxypregnenolone in the normo- and hyperandrogenemic polycystic ovary syndrome phenotypes. Materials and methods This cohort study was conducted at the Julio Muller University Hospital, Cuiabá, Brazil, between January 2014 and July 2016, and 91 normal cycling healthy women, 46 normoandrogenemic and 147 hyperandrogenemic, patients with polycystic ovary syndrome (PCOS) were enrolled according to the Rotterdam criteria. Several anthropometric, biochemical and hormonal parameters were properly verified and correlated with 17-hydroxypregnenolone (17-OHPE) concentrations. Results 17-OHPE was higher in hyperandrogenemic PCOS than in normoandrogenemic PCOS and in control groups (P = 0.032 and P R2 = 0.294, P Conclusion 17-OHPE exhibited different relationships with anthropometric, and biochemical parameters in PCOS patients, depending on the androgen levels. In PCOS subjects with high androgen concentrations, 17-OHPE was negatively associated with most anthropometric parameters, particularly with those used as markers of adipose tissue dysfunction and frequently employed as predictors of cardiovascular disease risk; otherwise, 17-OHPE was positively associated with HDL-C and HOMA-S in this patients. Future studies are required to evaluate the clinical implications of these novel findings.
- Subjects :
- medicine.medical_specialty
endocrine system diseases
17-hydroxypregnenolone
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Dehydroepiandrosterone
030209 endocrinology & metabolism
adrenal steroidogenesis
lcsh:Diseases of the endocrine glands. Clinical endocrinology
hyperandrogenism
hormone precursor
03 medical and health sciences
0302 clinical medicine
Endocrinology
Sex hormone-binding globulin
Internal medicine
Internal Medicine
medicine
lcsh:RC648-665
biology
business.industry
Research
Hyperandrogenism
nutritional and metabolic diseases
androgens
Stepwise regression
medicine.disease
Androgen
Polycystic ovary
polycystic ovary syndrome
Estrogen
030220 oncology & carcinogenesis
biology.protein
business
Cohort study
Subjects
Details
- ISSN :
- 20493614
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Endocrine Connections
- Accession number :
- edsair.doi.dedup.....4a38a2399727c19e0931d865d43c8ddc