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Method for improving the spatial resolution of narrow x-ray beam-based x-ray luminescence computed tomography imaging
- Source :
- Journal of Biomedical Optics, Journal of biomedical optics, vol 24, iss 8
- Publication Year :
- 2019
- Publisher :
- Society of Photo-Optical Instrumentation Engineers, 2019.
-
Abstract
- X-ray luminescence computed tomography (XLCT) is an emerging hybrid imaging modality which has the potential for achieving both high sensitivity and spatial resolution simultaneously. For the narrow x-ray beam-based XLCT imaging, based on previous work, a spatial resolution of about double the x-ray beam size can be achieved using a translate/rotate scanning scheme, taking step sizes equal to the x-ray beam width. To break the current spatial resolution limit, we propose a scanning strategy achieved by reducing the scanning step size to be smaller than the x-ray beam size. We performed four sets of numerical simulations and a phantom experiment using cylindrical phantoms and have demonstrated that our proposed scanning method can greatly improve the XLCT-reconstructed image quality compared with the traditional scanning approach. In our simulations, by using a fixed x-ray beam size of 0.8 mm, we were able to successfully reconstruct six embedded targets as small as 0.5 mm in diameter and with the same edge-to-edge distances by using a scanning step as small as 0.2 mm which is a 1.6 times improvement in the spatial resolution compared with the traditional approach. Lastly, the phantom experiment further demonstrated the efficacy of our proposed method in improving the XLCT image quality, with all image quality metrics improving as the step size decreased.
- Subjects :
- Paper
Optics and Photonics
Materials science
Luminescence
Image quality
Image Processing
Biomedical Engineering
Optical Physics
tomography
01 natural sciences
Phantoms
Imaging phantom
Imaging
010309 optics
Biomaterials
Computer-Assisted
Optics
Theoretical
Models
Opthalmology and Optometry
0103 physical sciences
Image Processing, Computer-Assisted
Computer Simulation
Sensitivity (control systems)
medical optics instrumentation
Image resolution
Beam diameter
x-ray luminescence
business.industry
Phantoms, Imaging
X-Rays
Equipment Design
Models, Theoretical
Atomic and Molecular Physics, and Optics
X-Ray Computed
Electronic, Optical and Magnetic Materials
Tomography
business
Tomography, X-Ray Computed
Beam (structure)
Algorithms
Subjects
Details
- Language :
- English
- ISSN :
- 15602281 and 10833668
- Volume :
- 24
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....4a50feaa5f692ced57f40e6d01c5e86c