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Shared Molecular Mechanisms of Hypertrophic Cardiomyopathy and Its Clinical Presentations: Automated Molecular Mechanisms Extraction Approach
- Source :
- Life, Vol 11, Iss 785, p 785 (2021), Life, Volume 11, Issue 8
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease with a prevalence of 1 in 500 people and varying clinical presentations. Although there is much research on HCM, underlying molecular mechanisms are poorly understood, and research on the molecular mechanisms of its specific clinical presentations is scarce. Our aim was to explore the molecular mechanisms shared by HCM and its clinical presentations through the automated extraction of molecular mechanisms. Molecular mechanisms were congregated by a query of the INDRA database, which aggregates knowledge from pathway databases and combines it with molecular mechanisms extracted from abstracts and open-access full articles by multiple machine-reading systems. The molecular mechanisms were extracted from 230,072 articles on HCM and 19 HCM clinical presentations, and their intersections were found. Shared molecular mechanisms of HCM and its clinical presentations were represented as networks<br />the most important elements in the intersections’ networks were found, centrality scores for each element of each network calculated, networks with reduced level of noise generated, and cooperatively working elements detected in each intersection network. The identified shared molecular mechanisms represent possible mechanisms underlying different HCM clinical presentations. Applied methodology produced results consistent with the information in the scientific literature.
- Subjects :
- 0301 basic medicine
Myocardial ischemia
Computer science
Science
cardiac fibrosis
molecular mechanisms
heart failure
Computational biology
macromolecular substances
030204 cardiovascular system & hematology
Article
General Biochemistry, Genetics and Molecular Biology
sudden cardiac death
03 medical and health sciences
0302 clinical medicine
left ventricular outflow tract obstruction
medicine
atrial fibrillation
cardiovascular diseases
Ecology, Evolution, Behavior and Systematics
automated curation
Hypertrophic cardiomyopathy
Paleontology
data mining
medicine.disease
hypertrophic cardiomyopathy
myocardial ischemia
030104 developmental biology
Space and Planetary Science
cardiovascular system
Subjects
Details
- Language :
- English
- ISSN :
- 20751729
- Volume :
- 11
- Issue :
- 785
- Database :
- OpenAIRE
- Journal :
- Life
- Accession number :
- edsair.doi.dedup.....4a59d4386c5328f622d79151095b21b4