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Platelet Transfusion Therapy
- Source :
- Hematology/Oncology Clinics of North America. 21:697-729
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- This article provides guidelines for the appropriate use of platelet transfusions to reduce unnecessary transfusions, thereby avoiding transfusion-related risks to the patients and the costs of platelet therapy. Platelet products available for transfusion are whole blood derived platelet concentrates and apheresis platelets. Leukoreduced platelets can be used to reduce platelet alloimmunization, cytomegalovirus transmission, and febrile transfusion reactions, while gamma irradiation prevents transfusion-associated graftversus-host disease. Other topics discussed are the expected response to transfused platelets and reasons for poor responses related to alloimmunization, underlying disease state, clinical conditions, and drugs. Appropriate transfusion guidelines based on pretransfusion platelet count, platelet dose, and whether the transfusion is prophylactic or therapeutic are outlined. Identification, prevention, and management of adverse consequences of platelet transfusions and platelet refractoriness are discussed.
- Subjects :
- Blood Platelets
medicine.medical_specialty
Hematology
Blood transfusion
Cell Survival
Platelet Count
business.industry
medicine.medical_treatment
Platelet Transfusion
medicine.disease
Treatment Outcome
Apheresis
Platelet transfusion
Blood Grouping and Crossmatching
Oncology
Blood product
Internal medicine
Anesthesia
Coagulopathy
Humans
Medicine
Platelet
business
Whole blood
Subjects
Details
- ISSN :
- 08898588
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Hematology/Oncology Clinics of North America
- Accession number :
- edsair.doi.dedup.....4a59e15f93315e67c348ae27c04c8486