Back to Search
Start Over
Differences in Importance Attached to Drug Effects Between Patients With Type 2 Diabetes From the Netherlands and Turkey: A Preference Study
- Source :
- Frontiers in Pharmacology, Frontiers in Pharmacology, Vol 11 (2021), FRONTIERS IN PHARMACOLOGY, Frontiers in Pharmacology, 11:617409. Frontiers Media SA
- Publication Year :
- 2020
-
Abstract
- Objective: The aim of this study was to compare the importance that patients with type 2 diabetes mellitus from the Netherlands and Turkey attach to certain drug effects of oral anti-diabetic drugs.Methods: Data were collected through a cross-sectional survey containing demographic questions and a discrete choice experiment assessing preferences for oral anti-diabetic drugs. Adults from the Netherlands and Turkey were included if they had type 2 diabetes mellitus and had received a prescription of an oral anti-diabetic drug in the last 4 months. The oral anti-diabetic drugs in the discrete choice experiment were described in terms of six attributes: effects on HbA1c, cardiovascular diseases, weight change, gastrointestinal adverse drug events hypoglycemic events, and bladder cancer. Multinomial logit models with country as an interaction factor were fitted.Results: In total, 381 patients were included, 199 from the Netherlands and 182 from Turkey. Patients’ preferences toward drug effects varied between the countries. Turkish patients attached the highest importance to reducing the risk of cardiovascular diseases (relative weight: 0.51, 95% CI 0.45–0.55), followed by reducing hypoglycemic events (relative weight: 0.16, 95% CI 0.11–0.22), and reducing gastrointestinal adverse drug events (relative weight: 0.11, 95% CI 0.07–0.18). Patients from the Netherlands attached the highest importance to gastrointestinal ADEs (relative weight: 0.22, 95% CI 0.14–0.39), followed by reducing hypoglycemic events (relative weight: 0.22, 95% CI 0.16–0.25), and reducing the risk of cardiovascular diseases (relative weight: 0.20, 95% CI 0.13–0.23).Conclusion: Patient preferences may differ across countries. Such differences should be acknowledged in regulatory decisions and clinical practice.
- Subjects :
- Drug
medicine.medical_specialty
Turkey
type 2 diabetes mellitus
media_common.quotation_subject
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
03 medical and health sciences
discrete-choice experiment
0302 clinical medicine
Internal medicine
Medicine
Pharmacology (medical)
Medical prescription
Multinomial logistic regression
media_common
Original Research
Pharmacology
Bladder cancer
business.industry
lcsh:RM1-950
Weight change
Type 2 Diabetes Mellitus
The Netherlands
medicine.disease
Preference
3. Good health
lcsh:Therapeutics. Pharmacology
business
patient preferences
Subjects
Details
- ISSN :
- 16639812
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in pharmacology
- Accession number :
- edsair.doi.dedup.....4a5a473366c296b5bfde8d42cafb4e96