Supplementary Video S1B from Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition

To demonstrate that the oral N-PPG treatment (treated flies in Suppl. Fig 3B panel A) phenocopies the Sluggish-A phenotype of SlgA null mutant flies as previously described (18), geotaxis of untreated SlgA mutant flies is video illustrated (right tube) and compared to that of untreated wildtype flies (left tube).