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HLA and age of onset in myasthenia gravis
- Source :
- Neuromuscular disorders : NMD. 27(7)
- Publication Year :
- 2017
-
Abstract
- The aetiology of MG is unknown, but both genetic and environmental factors are important. Over the years association of MG with Human Leucocyte Antigens (HLA) has been described in different populations. We investigated a possible association between HLA-DRB1 alleles and age of onset in MG. One hundred and fourteen MG patients (82 females) and 282 control individuals (CP) were studied. Patients were classified according to the age of onset (early-onset
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Thymoma
Genotype
Population
Human leukocyte antigen
Gastroenterology
Antibodies
03 medical and health sciences
0302 clinical medicine
Internal medicine
Myasthenia Gravis
medicine
HLA-DQ beta-Chains
Humans
Receptors, Cholinergic
Allele
Age of Onset
education
Allele frequency
Genetics (clinical)
Genetic Association Studies
Aged
education.field_of_study
business.industry
Middle Aged
medicine.disease
Myasthenia gravis
Doenças Genéticas
030104 developmental biology
Neurology
Pediatrics, Perinatology and Child Health
Immunology
Female
Neurology (clinical)
Age of onset
business
030217 neurology & neurosurgery
HLA-DRB1 Chains
Subjects
Details
- ISSN :
- 18732364
- Volume :
- 27
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Neuromuscular disorders : NMD
- Accession number :
- edsair.doi.dedup.....4a80c7eb31030245427bc28ae1cda066