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The urinary biopterin in autism spectrum disorder
- Source :
- Pteridines, Vol 32, Iss 1, Pp 17-22 (2021)
- Publication Year :
- 2021
- Publisher :
- Walter de Gruyter GmbH, 2021.
-
Abstract
- Objective The aim of the study was to determine whether biopterin is present in significantly lower quantities in urine samples of patients with autism spectrum disorder (ASD) compared to healthy individuals. Methods The concentration of biopterin in urine samples was measured by ELISA using commercially available kit. The study involved 53 children aged 3–16 years with ASD and 60 healthy children aged 2–14 years. Results Significantly lower biopterin concentration was observed in autistic patients compared to the control group. However, no significant difference was observed between mild, moderate, and severe ASD. Conclusion One of the potential causes of decrease in urinary biopterin levels may be tetrahydrobiopterin (BH4) deficiency, which has extensive and serious health consequences for the nervous system. The results of measuring biopterin as a fully oxidized form of BH4 may suggest that biosynthesis or regeneration of BH4 may be decreased in children with ASD. On the other hand, decreased urinary biopterin levels in children with ASD may be due to BH4 overuse, a good regeneration process, and decreased urinary excretion; and abnormalities in BH4 metabolism appear to be related to the aetiology of ASD or may be due to ASD.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Urinary system
Clinical Biochemistry
autism
Biopterin
behavioral disciplines and activities
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
mental disorders
medicine
Crystallography
business.industry
medicine.disease
urine
030104 developmental biology
Endocrinology
biopterin
chemistry
QD901-999
Autism spectrum disorder
tetrahydrobiopterin
pterins
Molecular Medicine
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 21954720
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Pteridines
- Accession number :
- edsair.doi.dedup.....4a842d51d290230e895a6925324032e7