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Effects of Transforming Growth Factor-βone Marrow Macrophage la Expression Induced by Cytokines
- Source :
- Journal of Interferon & Cytokine Research. 15:485-491
- Publication Year :
- 1995
- Publisher :
- Mary Ann Liebert Inc, 1995.
-
Abstract
- The initiation of the immune response is regulated, in part, by the effect of cytokines on the level of expression of major histocompatibility complex (MHC) class II antigens on antigen-presenting cells (APC). The expression of class II antigens on B cell and macrophage APC is induced by IFN-gamma and IL-4, and GM-CSF induces class II expression on macrophages (M phi). Our results show that transforming growth factor-beta (TGF-beta) inhibits IL-4- and GM-CSF-induced Ia gene expression on bone marrow macrophages but enhances IFN-gamma-induced gene expression. Nuclear run-on experiments demonstrated that the inhibitory effects of TGF-beta on GM-CSF- and IL-4-induced Ia antigen expression were primarily posttranscriptional and augmentation of IFN-gamma by TGF-beta was largely transcriptionally regulated.
- Subjects :
- Transcription, Genetic
Immunology
Bone Marrow Cells
Mice, Inbred Strains
Biology
Major histocompatibility complex
Interferon-gamma
Mice
Immune system
Antigen
Bone Marrow
Transforming Growth Factor beta
Virology
Gene expression
medicine
Animals
Macrophage
RNA, Messenger
RNA Processing, Post-Transcriptional
Cells, Cultured
B cell
Cell Line, Transformed
Antigen Presentation
Mice, Inbred BALB C
Mice, Inbred C3H
Macrophages
Histocompatibility Antigens Class II
Granulocyte-Macrophage Colony-Stimulating Factor
Cell Biology
Transforming growth factor beta
Macrophage Activation
Molecular biology
Recombinant Proteins
Cell biology
medicine.anatomical_structure
Gene Expression Regulation
biology.protein
Cytokines
Interleukin-4
Transforming growth factor
Subjects
Details
- ISSN :
- 15577465 and 10799907
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Journal of Interferon & Cytokine Research
- Accession number :
- edsair.doi.dedup.....4a8c771e3fc8d5d5a0e61e49813f5cb1