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Current treatment and surveillance modalities are not sufficient for advanced stage III colon cancer: Result from a multicenter cohort analysis
- Source :
- Cancer Medicine, Vol 10, Iss 24, Pp 8924-8933 (2021), Cancer Medicine
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Objective We conducted this multicenter cohort study to evaluate the current tumor‐node‐metastasis staging system and treatment modality by analyzing the survival outcomes of patient groups with stage III and IV colon cancer. Patients and Methods Stage III and IV colon cancer patients from the Surveillance, Epidemiology, and End Results (SEER) database (SEER cohort) and prospectively maintained Sun Yat‐sen University (SYSU) cohort were included in this study. Kaplan‐Meier method was used to estimate the cumulative rate of overall survival (OS) between patient groups, and the inverse probability weighting method was used to calculated age and sex‐adjusted survival curves. The Cox regression model was used to identify the risk factors for OS. Results A total of 17,911 and 1135 stage III–IV cases were included in the SEER and SYSU cohorts, respectively. Among them, 1448 and 124 resectable stage IV cases underwent curative‐intent treatment in the SEER and SYSU cohorts, respectively. The T4N2b group showed a significantly worse survival outcome compared with the M1a subset receiving curative‐intent treatment (HR, 1.46; p<br />By analyzing the Surveillance, Epidemiology, and End Results database and in‐house cohorts, several stage III subgroups were identified in a high risk of death, especially the T4N2b group that had significantly worse overall survival than that of the M1a subset. When further categorized by risk factors, the survival of the high‐risk T4N2b patients was worse than that of the M1b subset.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Multivariate analysis
Colorectal cancer
colorectal cancer
advanced stage
survival
Cohort Studies
Chronic Disease Indicators
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Stage (cooking)
Research Articles
Survival analysis
RC254-282
Aged
Neoplasm Staging
treatment
Proportional hazards model
business.industry
Clinical Cancer Research
Cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
tumor staging
Middle Aged
Prognosis
medicine.disease
Survival Analysis
SEER
Colonic Neoplasms
Cohort
Female
business
management
Research Article
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 10
- Issue :
- 24
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....4a99ae5dcdd0694c294c4e785b5ae024