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Mucosal immunization in macaques upregulates the innate APOBEC 3G anti-viral factor in CD4+ memory T cells

Mucosal immunization in macaques upregulates the innate APOBEC 3G anti-viral factor in CD4+ memory T cells

Authors :
Neil Berry
Richard Stebbings
Yufei Wang
Thomas Seidl
Neil Almond
Mahavir Singh
Lesley A. Bergmeier
Thomas Lehner
Trevor Whittall
Source :
Vaccine. 27:870-881
Publication Year :
2009
Publisher :
Elsevier BV, 2009.

Abstract

APOBEC3G is an innate intracellular anti-viral factor which deaminates retroviral cytidine to uridine. In vivo studies of APOBEC3G (A3G) were carried out in rhesus macaques, following mucosal immunization with SIV antigens and CCR5 peptides, linked to the 70kDa heat shock protein. A progressive increase in A3G mRNA was elicited in PBMC after each immunization (p

Details

ISSN :
0264410X
Volume :
27
Database :
OpenAIRE
Journal :
Vaccine
Accession number :
edsair.doi.dedup.....4aa6d97747d9f5a7ac121875bf4d1bc9
Full Text :
https://doi.org/10.1016/j.vaccine.2008.11.084