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Effects of Adjuvant Radiotherapy in Patients With Synovial Sarcoma

Authors :
Junghwan Park
Han-Soo Kim
Ilkyu Han
Sanghyuk Song
Suzy Kim
Hak Jae Kim
Il Han Kim
Source :
American Journal of Clinical Oncology. 40:306-311
Publication Year :
2017
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2017.

Abstract

To analyze the treatment outcomes and the effects of adjuvant radiotherapy (RT) in patients with synovial sarcoma (SS). The medical records of 103 patients treated with definitive surgery for SS, with/without RT, from August 1982 to July 2013 were reviewed retrospectively. The median age of the patients was 33 years (range, 5 to 72 y). The most frequent tumor location was the extremities (79 patients, 77%). Seventy-five patients (73%) received adjuvant RT and 26 (25%) did not. The median dose of adjuvant RT was 61.2 Gy (range, 45 to 66.6 Gy). The median follow-up period was 5.4 years (range, 0.2 to 31.0 y). The 5- and 10-year overall survival rates were 77 % and 65%, respectively. The progression-free survival (PFS) rates at 5 and 10 years were 52% and 43%, respectively. The most common site of initial failure was the lung (24 patients), followed by local recurrence (14 patients). The 5-year local-recurrence-free survival (LRFS) and distant-metastasis-free survival (DMFS) rates were 80% and 63%, respectively. On multivariate analysis, a mitosis count of

Details

ISSN :
02773732
Volume :
40
Database :
OpenAIRE
Journal :
American Journal of Clinical Oncology
Accession number :
edsair.doi.dedup.....4ac02dca19738d2c0ce6d5cf9cccea71
Full Text :
https://doi.org/10.1097/coc.0000000000000148