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Significance of adding progesterone to the Risk of Ovarian Malignancy Algorithm for early stage ovarian cancer detection in patients with a pelvic mass : a single-center case-control study
- Source :
- Taiwanese Journal of Obstetrics & Gynecology, Vol 54, Iss 6, Pp 766-772 (2015)
- Publication Year :
- 2015
-
Abstract
- Objective To evaluate the clinical significance of the combination of cancer antigen-125 (CA-125), human epididymis protein 4 (HE4), and progesterone for the identification of ovarian masses in patients with suspected early stage ovarian cancer (OC). Materials and methods This was a case–control, single-center study of 225 women with a pelvic mass of suspected ovarian origin, including 75 patients with Stage I/II OC and 150 controls. Diagnostic procedures included pelvic and rectal examinations, transvaginal ultrasound, evaluation of CA-125 and HE4 levels alone and in the Risk of Ovarian Malignancy Algorithm (ROMA), and a new algorithm combining ROMA and progesterone. Results Median CA-125 and HE4 levels were significantly higher in patients with OC compared with women with benign ovarian tumors, irrespective of menopausal status. The highest median progesterone levels occurred in premenopausal women with benign ovarian tumors, compared with premenopausal women with OC with or without benign ovarian disease. The combination of ROMA and progesterone was significantly more accurate at detecting OC compared with ROMA or CA-125 or HE4 alone, but only in premenopausal patients. Conclusion Different algorithms should be used for diagnosing OC, and the addition of progesterone might improve the performance of ROMA for the diagnosis of pelvic masses in premenopausal women.
- Subjects :
- medicine.medical_specialty
progesterone
Single Center
lcsh:Gynecology and obstetrics
Ovarian disease
WAP Four-Disulfide Core Domain Protein 2
Obstetrics and Gynaecology
Biomarkers, Tumor
medicine
Humans
human epididymis protein 4
Clinical significance
In patient
Stage (cooking)
Early Detection of Cancer
lcsh:RG1-991
Ovarian Neoplasms
Gynecology
ROMA
business.industry
Case-control study
Proteins
Obstetrics and Gynecology
Cancer
Middle Aged
medicine.disease
ovarian cancer
Premenopause
cancer antigen-125
CA-125 Antigen
Case-Control Studies
Female
business
Ovarian cancer
Algorithm
Algorithms
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Taiwanese Journal of Obstetrics & Gynecology, Vol 54, Iss 6, Pp 766-772 (2015)
- Accession number :
- edsair.doi.dedup.....4ad525ca52c7d8ebdb0d025b75dced72