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Acute kidney injury in infective endocarditis: A retrospective analysis
- Source :
- Médecine et Maladies Infectieuses, Médecine et Maladies Infectieuses, Elsevier Masson, 2019, 49, pp.527-533. ⟨10.1016/j.medmal.2019.03.015⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Acute kidney injury (AKI) is associated with high case fatality in infective endocarditis (IE), but epidemiological data on the frequency of AKI during IE is scarce. We aimed to describe the frequency and risk factors for AKI during the course of IE using Kidney Disease: Improving Global Outcomes consensual criteria.Using the French hospital discharge database (French acronym PMSI), we retrospectively reviewed the charts of 112 patients presenting with a first episode of probable or definite IE between January 2010 and May 2015.Seventy-seven patients (68.8%) developed AKI. In univariate analysis, risk factors for AKI were cardiac surgery for IE (n=29, 37.7% vs. n=4, 1.4%, P0.0005), cardiac failure (n=29, 36.7% vs. n=1, 2.9%, P0.0005), diabetes mellitus (n=14, 18.2% vs. n=1, 0.9%, P=0.034), and prosthetic valve IEs (n=24, 31.2% vs. n=4, 11.4%). No differences were observed for gentamicin exposure (n=57, 64% vs. n=32, 86.5%, P=0.286). Prosthetic valve IE, cardiac failure, and vancomycin exposure were independently associated with AKI with respective odds ratio of 5.49 (95% CI 1.92-17.9), 4.37 (95% CI 4.37-465.7), and 1.084 (1.084-16.2). Mean length of hospital stay was significantly longer in patients presenting with AKI than in controls (respectively 52.4±22.1 days vs. 39.6±12.6, P0.005).AKI is very frequent during IE, particularly in patients with prosthetic valve IE, cardiac failure, and those receiving vancomycin.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
[SDV]Life Sciences [q-bio]
urologic and male genital diseases
03 medical and health sciences
Young Adult
Risk Factors
Internal medicine
Case fatality rate
Epidemiology
Medicine
Endocarditis
Humans
Aged
Retrospective Studies
First episode
Aged, 80 and over
0303 health sciences
Univariate analysis
urogenital system
030306 microbiology
business.industry
Acute kidney injury
Acute Kidney Injury
Middle Aged
medicine.disease
female genital diseases and pregnancy complications
3. Good health
Infectious Diseases
Infective endocarditis
Female
business
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 0399077X
- Database :
- OpenAIRE
- Journal :
- Médecine et Maladies Infectieuses, Médecine et Maladies Infectieuses, Elsevier Masson, 2019, 49, pp.527-533. ⟨10.1016/j.medmal.2019.03.015⟩
- Accession number :
- edsair.doi.dedup.....4ae8f5e3b7c30f8d3460a2346ab9290c