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Effect of Smoking on Blood Pressure and Resting Heart Rate - A Mendelian Randomization Meta-Analysis in the CARTA Consortium
- Source :
- Circulation: Cardiovascular genetics, 8(6), 832-841. American Heart Association, Circulation: Cardiovascular Genetics, 8(6), 832-841, Linneberg, A, Jacobsen, R K, Skaaby, T, Taylor, A E, Fluharty, M E, Jeppesen, J L, Bjørngaard, J H, Åsvold, B O, Gabrielsen, M E, Campbell, A, Marioni, R E, Kumari, M, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Ahluwalia, T S, Wannamethee, S G, Lahti, J, Räikkönen, K, Palotie, A, Wong, A, Dalgård, C, Ford, I, Ben-Shlomo, Y, Christiansen, L, Kyvik, K O, Kuh, D, Eriksson, J G, Whincup, P H, Mbarek, H, de Geus, E J C, Vink, J M, Boomsma, D I, Davey Smith, G, Lawlor, D A, Kisialiou, A, McConnachie, A, Padmanabhan, S, Jukema, J W, Power, C, Hyppönen, E, Preisig, M, Waeber, G, Vollenweider, P, Korhonen, T, Laatikainen, T, Salomaa, V, Kaprio, J, Kivimäki, M, Smith, B H, Hayward, C, Sørensen, T I A, Thuesen, B H, Sattar, N, Morris, R W, Romundstad, P R, Munafò, M R, Jarvelin, M-R & Husemoen, L L N 2015, ' Effect of Smoking on Blood Pressure and Resting Heart Rate : A Mendelian Randomization Meta-Analysis in the CARTA Consortium ', Circulation: Cardiovascular Genetics, vol. 8, no. 6, pp. 832-841 . https://doi.org/10.1161/CIRCGENETICS.115.001225, Linneberg, A, Jacobsen, R K, Skaaby, T, Taylor, A E, Fluharty, M E, Jeppesen, J, Bjorngaard, J H, Asvold, B O, Gabrielsen, M E, Campbell, A, Marioni, R E, Kumari, M, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Ahluwalia, T S, Wannamethee, S G, Lahti, J, Räikkönen, K, Palotie, A, Wong, A, Dalgard, C, Ford, I, Ben-Shlomo, Y, Christiansen, L, Kyvik, K O, Kuh, D, Eriksson, J G, Whincup, P H, Mbarek, H, de Geus, E J C, Vink, J M, Boomsma, D I, Davey Smith, G, Lawlor, D A, Kisialiou, A, McConnachie, A, Padmanabhan, S, Jukema, J W, Power, C, Hyppönen, E, Preisig, M, Waeber, G, Vollenweider, P, Korhonen, T, Laatikainen, T, Salomaa, V, Kaprio, J, Kivimaki, M, Smith, B H, Hayward, C, Sorensen, T I A, Thuesen, B H, Sattar, N, Morris, R W, Romundstad, P R, Munafò, M, Jarvelin, M R & Husemoen, L L N 2015, ' Effect of Smoking on Blood Pressure and Resting Heart Rate-A Mendelian Randomization Meta-Analysis in the CARTA Consortium ', Circulation: Cardiovascular genetics, vol. 8, no. 6, pp. 832-841 . https://doi.org/10.1161/CIRCGENETICS.115.001225, Circulation. Cardiovascular Genetics, 8, 6, pp. 832-841, Circulation. Cardiovascular Genetics, 8, 832-841, Circulation. Cardiovascular Genetics, vol. 8, no. 6, pp. 832-841, Linneberg, A, Jacobsen, R K, Skaaby, T, Taylor, A E, Fluharty, M E, Jeppesen, J L, Bjorngaard, J H, Åsvold, B O, Gabrielsen, M E, Campbell, A, Marioni, R E, Kumari, M, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Ahluwalia, T S, Wannamethee, S G, Lahti, J, Raikkonen, K, Palotie, A, Wong, A, Dalgård, C, Ford, I, Ben-Shlomo, Y, Christiansen, L, Kyvik, K O, Kuh, D J L, Eriksson, J G, Whincup, P H, Mbarek, H, De Geus, E J C, Vink, J M, Boomsma, D I, Smith, G D, Lawlor, D A, Kisialiou, A, McConnachie, A, Padmanabhan, S, Jukema, J W, Power, C, Hypponen, E, Preisig, M, Waeber, G, Vollenweider, P, Korhonen, T, Laatikainen, T, Salomaa, V, Kaprio, J, Kivimaki, M J, Smith, B H, Hayward, C, Sorensen, T, Thuesen, B H, Sattar, N, Morris, R W, Romundstad, P R, Munafò, M R, Jarvelin, M R & Husemoen, L L N 2015, ' Effect of Smoking on Blood Pressure and Resting Heart Rate : A Mendelian Randomization Meta-Analysis in the CARTA Consortium ', Circulation: Cardiovascular Genetics, vol. 8, no. 6, pp. 832-841 . https://doi.org/10.1161/CIRCGENETICS.115.001225
- Publication Year :
- 2015
-
Abstract
- Background— Smoking is an important cardiovascular disease risk factor, but the mechanisms linking smoking to blood pressure are poorly understood. Methods and Results— Data on 141 317 participants (62 666 never, 40 669 former, 37 982 current smokers) from 23 population-based studies were included in observational and Mendelian randomization meta-analyses of the associations of smoking status and smoking heaviness with systolic and diastolic blood pressure, hypertension, and resting heart rate. For the Mendelian randomization analyses, a genetic variant rs16969968/rs1051730 was used as a proxy for smoking heaviness in current smokers. In observational analyses, current as compared with never smoking was associated with lower systolic blood pressure and diastolic blood pressure and lower hypertension risk, but with higher resting heart rate. In observational analyses among current smokers, 1 cigarette/day higher level of smoking heaviness was associated with higher (0.21 bpm; 95% confidence interval 0.19; 0.24) resting heart rate and slightly higher diastolic blood pressure (0.05 mm Hg; 95% confidence interval 0.02; 0.08) and systolic blood pressure (0.08 mm Hg; 95% confidence interval 0.03; 0.13). However, in Mendelian randomization analyses among current smokers, although each smoking increasing allele of rs16969968/rs1051730 was associated with higher resting heart rate (0.36 bpm/allele; 95% confidence interval 0.18; 0.54), there was no strong association with diastolic blood pressure, systolic blood pressure, or hypertension. This would suggest a 7 bpm higher heart rate in those who smoke 20 cigarettes/day. Conclusions— This Mendelian randomization meta-analysis supports a causal association of smoking heaviness with higher level of resting heart rate, but not with blood pressure. These findings suggest that part of the cardiovascular risk of smoking may operate through increasing resting heart rate.
- Subjects :
- Male
Netherlands Twin Register (NTR)
Pathology
Cardiac & Cardiovascular Systems
Hypertension/etiology
Blood Pressure
Brain and Behaviour
RESTING HEART RATE
Heart Rate
GENETIC-VARIANTS
Smoking/adverse effects
Genetics (clinical)
GENERAL-POPULATION SAMPLE
ALL-CAUSE MORTALITY
Genetics & Heredity
education.field_of_study
Tobacco and Alcohol
Smoking
blood pressure
Heart Rate/genetics
ASSOCIATION
CARDIOVASCULAR-DISEASE
Meta-analysis
Cardiology
Female
Cardiology and Cardiovascular Medicine
Life Sciences & Biomedicine
medicine.medical_specialty
hypertension
Blood Pressure/genetics
Population
Heart rate
1102 Cardiovascular Medicine And Haematology
Article
smoking
SDG 3 - Good Health and Well-being
Internal medicine
Mendelian randomization
Genetics
medicine
Humans
education
Alleles
0604 Genetics
Science & Technology
business.industry
CONSUMPTION
Confidence interval
NICOTINE DEPENDENCE
Blood pressure
Cardiovascular System & Hematology
Cardiovascular System & Cardiology
RISK-FACTORS
Observational study
CESSATION
business
Developmental Psychopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1942325X
- Database :
- OpenAIRE
- Journal :
- Circulation: Cardiovascular genetics, 8(6), 832-841. American Heart Association, Circulation: Cardiovascular Genetics, 8(6), 832-841, Linneberg, A, Jacobsen, R K, Skaaby, T, Taylor, A E, Fluharty, M E, Jeppesen, J L, Bjørngaard, J H, Åsvold, B O, Gabrielsen, M E, Campbell, A, Marioni, R E, Kumari, M, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Ahluwalia, T S, Wannamethee, S G, Lahti, J, Räikkönen, K, Palotie, A, Wong, A, Dalgård, C, Ford, I, Ben-Shlomo, Y, Christiansen, L, Kyvik, K O, Kuh, D, Eriksson, J G, Whincup, P H, Mbarek, H, de Geus, E J C, Vink, J M, Boomsma, D I, Davey Smith, G, Lawlor, D A, Kisialiou, A, McConnachie, A, Padmanabhan, S, Jukema, J W, Power, C, Hyppönen, E, Preisig, M, Waeber, G, Vollenweider, P, Korhonen, T, Laatikainen, T, Salomaa, V, Kaprio, J, Kivimäki, M, Smith, B H, Hayward, C, Sørensen, T I A, Thuesen, B H, Sattar, N, Morris, R W, Romundstad, P R, Munafò, M R, Jarvelin, M-R & Husemoen, L L N 2015, ' Effect of Smoking on Blood Pressure and Resting Heart Rate : A Mendelian Randomization Meta-Analysis in the CARTA Consortium ', Circulation: Cardiovascular Genetics, vol. 8, no. 6, pp. 832-841 . https://doi.org/10.1161/CIRCGENETICS.115.001225, Linneberg, A, Jacobsen, R K, Skaaby, T, Taylor, A E, Fluharty, M E, Jeppesen, J, Bjorngaard, J H, Asvold, B O, Gabrielsen, M E, Campbell, A, Marioni, R E, Kumari, M, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Ahluwalia, T S, Wannamethee, S G, Lahti, J, Räikkönen, K, Palotie, A, Wong, A, Dalgard, C, Ford, I, Ben-Shlomo, Y, Christiansen, L, Kyvik, K O, Kuh, D, Eriksson, J G, Whincup, P H, Mbarek, H, de Geus, E J C, Vink, J M, Boomsma, D I, Davey Smith, G, Lawlor, D A, Kisialiou, A, McConnachie, A, Padmanabhan, S, Jukema, J W, Power, C, Hyppönen, E, Preisig, M, Waeber, G, Vollenweider, P, Korhonen, T, Laatikainen, T, Salomaa, V, Kaprio, J, Kivimaki, M, Smith, B H, Hayward, C, Sorensen, T I A, Thuesen, B H, Sattar, N, Morris, R W, Romundstad, P R, Munafò, M, Jarvelin, M R & Husemoen, L L N 2015, ' Effect of Smoking on Blood Pressure and Resting Heart Rate-A Mendelian Randomization Meta-Analysis in the CARTA Consortium ', Circulation: Cardiovascular genetics, vol. 8, no. 6, pp. 832-841 . https://doi.org/10.1161/CIRCGENETICS.115.001225, Circulation. Cardiovascular Genetics, 8, 6, pp. 832-841, Circulation. Cardiovascular Genetics, 8, 832-841, Circulation. Cardiovascular Genetics, vol. 8, no. 6, pp. 832-841, Linneberg, A, Jacobsen, R K, Skaaby, T, Taylor, A E, Fluharty, M E, Jeppesen, J L, Bjorngaard, J H, Åsvold, B O, Gabrielsen, M E, Campbell, A, Marioni, R E, Kumari, M, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Ahluwalia, T S, Wannamethee, S G, Lahti, J, Raikkonen, K, Palotie, A, Wong, A, Dalgård, C, Ford, I, Ben-Shlomo, Y, Christiansen, L, Kyvik, K O, Kuh, D J L, Eriksson, J G, Whincup, P H, Mbarek, H, De Geus, E J C, Vink, J M, Boomsma, D I, Smith, G D, Lawlor, D A, Kisialiou, A, McConnachie, A, Padmanabhan, S, Jukema, J W, Power, C, Hypponen, E, Preisig, M, Waeber, G, Vollenweider, P, Korhonen, T, Laatikainen, T, Salomaa, V, Kaprio, J, Kivimaki, M J, Smith, B H, Hayward, C, Sorensen, T, Thuesen, B H, Sattar, N, Morris, R W, Romundstad, P R, Munafò, M R, Jarvelin, M R & Husemoen, L L N 2015, ' Effect of Smoking on Blood Pressure and Resting Heart Rate : A Mendelian Randomization Meta-Analysis in the CARTA Consortium ', Circulation: Cardiovascular Genetics, vol. 8, no. 6, pp. 832-841 . https://doi.org/10.1161/CIRCGENETICS.115.001225
- Accession number :
- edsair.doi.dedup.....4afb58e1c247eac005b63906c9dbcf08
- Full Text :
- https://doi.org/10.1161/CIRCGENETICS.115.001225