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Progress and prospects for blood-stage malaria vaccines
- Source :
- Expert Review of Vaccines
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- There have been significant decreases in malaria mortality and morbidity in the last 10-15 years, and the most advanced pre-erythrocytic malaria vaccine, RTS,S, received a positive opinion from European regulators in July 2015. However, no blood-stage vaccine has reached a phase III trial. The first part of this review summarizes the pros and cons of various assays and models that have been and will be used to predict the efficacy of blood-stage vaccines. In the second part, blood-stage vaccine candidates that showed some efficacy in human clinical trials or controlled human malaria infection models are discussed. Then, candidates under clinical investigation are described in the third part, and other novel candidates and strategies are reviewed in the last part.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Plasmodium falciparum
Immunology
Blood stage malaria
in vitro assays
Review
challenge models
03 medical and health sciences
blood-stage
vaccine
Clinical investigation
Malaria Vaccines
parasitic diseases
Drug Discovery
medicine
Humans
Intensive care medicine
Pharmacology
Clinical Trials as Topic
biology
Malaria vaccine
business.industry
clinical trial
medicine.disease
biology.organism_classification
Malaria
Clinical trial
Blood stage
030104 developmental biology
Molecular Medicine
business
Subjects
Details
- ISSN :
- 17448395 and 14760584
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Expert Review of Vaccines
- Accession number :
- edsair.doi.dedup.....4b3dea9f0a12b7ab6a9cdbb2fa09d546