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Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples
- Source :
- Talanta. 144:456-465
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- A sensitive electrochemical sensor for determination of phenothiazine (PTZ) was introduced based on molecularly imprinted polymer (MIP) film. A computational study was performed to evaluate the template-monomer geometry and interaction energy in the prepolymerization mixture. The electrode was prepared during electropolymerization of pyrrole (Py) on a pencil graphite electrode (PGE) by cyclic voltammetry (CV) technique. The quantitative measurements were performed using differential pulse voltammetry (DPV) in Britton-Robinson (BR) buffer solutions using 60% (v/v) acetonitrile-water (ACN/H2O) binary solvent. The effect of important parameters like pH, monomer concentration, number of cycles, etc on the efficiency of MIP electrode was optimized and the calibration curve was plotted at optimal conditions. Two dynamic linear ranges of 1-300 µmol L(-1) and 0.5-10 mmol L(-1) were observed. The detection limit (based on S/N=3) of PTZ was obtained 3×10(-7) mol L(-1). The MIP/PGE has been successfully applied as a selective sensor for fast and accurate determination of PTZ in some model and real biological samples.
- Subjects :
- Meat
Polymers
Calibration curve
Antiprotozoal Agents
Analytical chemistry
Food Contamination
Polypyrrole
Analytical Chemistry
Molecular Imprinting
chemistry.chemical_compound
Phenothiazines
Animals
Pyrroles
Electrodes
Detection limit
Sheep
Fishes
Molecularly imprinted polymer
Electrochemical Techniques
Electrochemical gas sensor
Seafood
chemistry
Electrode
Cattle
Graphite
Differential pulse voltammetry
Cyclic voltammetry
Chickens
Subjects
Details
- ISSN :
- 00399140
- Volume :
- 144
- Database :
- OpenAIRE
- Journal :
- Talanta
- Accession number :
- edsair.doi.dedup.....4b569d819ca4d231b13b1f03c106d77d