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Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines
- Source :
- Phytochemistry Letters
- Publication Year :
- 2013
-
Abstract
- Five new sesquiterpene lactones (1-5) were isolated from Inula britannica collected in the wild from Serbia along with five known compounds (6-10). Sesquiterpene lactones were isolated using centrifugal partition chromatography followed by combination of flash chromatography and semi-preparative HPLC. Isolated compounds were screened for cytotoxic activity on four different human cancer cell lines and their multi-drug resistant counterparts, as well as on normal human keratinocytes. Sesquiterpene lactones showed similar cytotoxic activity toward drug sensitive and drug resistant cancer cell lines. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved. European Union [227448]; Center for Biosystems Genomics part of the Netherlands Genomics Initiative; Netherlands Metabolomics Center part of the Netherlands Genomics Initiative
- Subjects :
- biology
Traditional medicine
010405 organic chemistry
Stereochemistry
Plant Science
Asteraceae
biology.organism_classification
Sesquiterpene
01 natural sciences
Biochemistry
High-performance liquid chromatography
0104 chemical sciences
3. Good health
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Column chromatography
Inula britannica
chemistry
Cell culture
biology.protein
Cytotoxic T cell
Agronomy and Crop Science
Biotechnology
P-glycoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 18743900
- Volume :
- 6
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Phytochemistry Letters
- Accession number :
- edsair.doi.dedup.....4b63828b987ba50d618a1024b079dbfd
- Full Text :
- https://doi.org/10.1016/j.phytol.2013.02.006