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Iron Deficiency Anemia in Celiac Disease
- Source :
- Nutrients, Vol 13, Iss 1695, p 1695 (2021), Nutrients
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The iron absorption process developsmainly in the proximal duodenum. This portion of the intestine is typically destroyed in celiac disease (CD), resulting in a reduction in absorption of iron and subsequent iron deficiency anemia (IDA). In fact, the most frequent extra-intestinal manifestation (EIM) of CD is IDA, with a prevalence between 12 and 82% (in relation with the various reports) in patients with new CD diagnosis. The primary treatment of CD is the gluten-free diet (GFD), which is associated with adequate management of IDA, if present. Iron replacement treatment historically has been based on oral products containing ferrous sulphate (FS). However, the absorption of FS is limited in patients with active CD and unpredictable in patients on a GFD. Furthermore, a poor tolerability of this kind of ferrous is particularly frequent in patients with CD or with other inflammatory bowel diseases. Normalization from anemic state typically occurs after at least 6 months of GFD, but the process can take up to 2 years for iron stores to replenish.
- Subjects :
- medicine.medical_specialty
Duodenum
Iron
Iron absorption
Review
Disease
Gastroenterology
Ferrous
Diet, Gluten-Free
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Celiac disease
In patient
TX341-641
030212 general & internal medicine
Nutrition and Dietetics
Anemia, Iron-Deficiency
business.industry
Nutrition. Foods and food supply
iron absorption
Inflammatory Bowel Diseases
Iron Deficiencies
medicine.disease
Iron deficiency Anemia
Intestinal Absorption
Tolerability
Iron-deficiency anemia
030211 gastroenterology & hepatology
business
Food Science
Proximal duodenum
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 1695
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....4b85c439e50ba63cb4391ea8e1380b53