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A new internal target system for production of 211At on the cyclotron U-120M

Authors :
Jan Stursa
Jan Ráliš
Ondřej Lebeda
R. Jiran
Source :
Applied Radiation and Isotopes. 63:49-53
Publication Year :
2005
Publisher :
Elsevier BV, 2005.

Abstract

The alpha emitter (211)At is a radionuclide with good potential for use in the therapy of smaller tumours and metastases. However, limited availability of this radionuclide hinders development of this application and the research of astatine chemistry in general. In this general context we have designed and tested a new internal target system. A thin bismuth layer (3-5 microm) was evaporated onto a light target backing (7.5 g) and irradiated at 0.5-1.5 degrees angles with 29.5 MeV alpha particles beam of intensity up to 30 microA. The backing was then released from the target holder and used directly for astatine separation via dry distillation. Astatine condensed on the Teflon capillary walls was then eluted into 150-250 microl of methanol. The saturation yield was found to be ca. 400 MBq/microA, and the radionuclidic purity of (211)At acceptable for medical applications (activity ratio (210)At/(211)At

Details

ISSN :
09698043
Volume :
63
Database :
OpenAIRE
Journal :
Applied Radiation and Isotopes
Accession number :
edsair.doi.dedup.....4ba10a8cf45fb829e1afd1922aedad9d
Full Text :
https://doi.org/10.1016/j.apradiso.2005.02.006