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Use of misoprostol in the treatment of postpartum hemorrhage: a pharmacoepidemiological approach
- Source :
- einstein (São Paulo) v.18 2020, Einstein (São Paulo), Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE), instacron:IIEPAE, Einstein
- Publication Year :
- 2020
- Publisher :
- Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2020.
-
Abstract
- Objective To characterize the use of the drug misoprostol for treatment of postpartum hemorrhage in pregnant women. Methods A descriptive observational study was carried out with secondary data from pregnant women who used misoprostol to treat postpartum hemorrhage in a reference public maternity, from July 2015 to June 2017. Clinical and sociodemographic profiles of pregnant women, how misoprostol was used and success rate in controling postpartum hemorrhage were characterized. Results A total of 717 prescriptions of misoprostol were identified. Of these, 10% were for treatment of postpartum hemorrhage. The majority of pregnant women were young adults, married, with complete high school education, white, residing in urban areas, multiparous (68.1%) and 25% had previous cesarean sections. The mean gestational age was 39 weeks and 51.4% had a cesarean section. There was prophylactic use of oxytocin in 47.2% of women. Treatment of postpartum hemorrhage was successful in 84.7% of women. Of these, 79.2% also used oxytocin and 54.2% methylergonovine. Only 13.5% of pregnant women had less than five prenatal visits, and the main cause of postpartum hemorrhage was uterine atony. There were 13 complications after hemorrhage, 15.3% required blood transfusion and there was one case of maternal death. Conclusion Misoprostol showed to be effective and safe for treating postpartum hemorrhage.
- Subjects :
- Adult
medicine.medical_specialty
Blood transfusion
Cross-sectional study
medicine.medical_treatment
Gestational Age
Oxytocin
03 medical and health sciences
Young Adult
0302 clinical medicine
Methylergonovine
Pregnancy
Oxytocics
medicine
Humans
030212 general & internal medicine
Young adult
Treatment outcome
Misoprostol
reproductive and urinary physiology
business.industry
Obstetrics
Pharmacoepidemiology
Artigo Original
Postpartum Hemorrhage
Gestational age
General Medicine
Parto obstétrico
medicine.disease
Uterine atony
Postpartum hemorrhage
Resultado do tratamento
Cross-Sectional Studies
030220 oncology & carcinogenesis
Medicine
Maternal death
Original Article
Female
Delivery, obstetric
business
Hemorragia pós-parto
medicine.drug
Farmacoepidemiologia
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- einstein (São Paulo) v.18 2020, Einstein (São Paulo), Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE), instacron:IIEPAE, Einstein
- Accession number :
- edsair.doi.dedup.....4ba5e733ac73a18bd7fb6f05a475900e