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Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population
- Source :
- Disease markers, Disease Markers, Vol 29, Iss 1, Pp 37-46 (2010)
- Publication Year :
- 2010
- Publisher :
- IOS Press, 2010.
-
Abstract
- Matrix metalloproteinases (MMPs) contribute to tumor invasion and microenvironment, hence are associated with bladder cancer risk. We therefore, tested whether polymorphisms in MMP genes modify the risk of bladder cancer (BC) and whether smoke exposure modifies this risk.Genotyping was performed in 200 BC patients and 200 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).MMP1-1607 2G/2G andMMP7-181 GG genotype were associated with increased risk of BC (pMMP1-519-1607 (p< 0.001; OR, 2.62; 95% CI1.68–4.09). The 2G allele carrier (1G/2G + 2G/2G) ofMMP1-1607 showed a protective effect and high recurrence free survival in Bacillus Calmette-Guerin (BCG) treated non muscle invasive BC (NMIBC) patients (log rank p, 0.030). Our datasuggested that MMP11607 2G and MMP7181 G allele were associated with high risk of BC, which was quite evident amongst smokers too. BCG treated NMIBC patients reflected protective effect for 2G allele carrier (1G/2G+2G/2G) ofMMP1-1607. This study provided new support for the association of MMP1-1607 and MMP7-181 in bladder cancer development, the tumorigenic effect of which was observed to be more enhanced in case of tobacco exposure.
- Subjects :
- Male
haplotypes
matrix metalloproteinase
Genotype
Clinical Biochemistry
India
recurrence free survival
polymorphism
Bacillus Calmette-Guérin
Genetics
Humans
Genetic Predisposition to Disease
Molecular Biology
lcsh:R5-920
Polymorphism, Genetic
Biochemistry (medical)
Smoking
General Medicine
Urinary Bladder Neoplasms
Case-Control Studies
Matrix Metalloproteinase 7
BCG Vaccine
bladder cancer
Female
Other
Matrix Metalloproteinase 1
lcsh:Medicine (General)
Subjects
Details
- Language :
- English
- ISSN :
- 18758630 and 02780240
- Volume :
- 29
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Disease markers
- Accession number :
- edsair.doi.dedup.....4bae73379a20362a25a8dd93a53a362e