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Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With the Crohn Disease Activity Index
- Source :
- Clinical Medicine Insights: Gastroenterology, Vol 11 (2018), Clinical Medicine Insights. Gastroenterology
- Publication Year :
- 2018
- Publisher :
- SAGE Publications, 2018.
-
Abstract
- We aimed to clarify the relationship between plasma-free amino acid (PFAA) profiles and the Crohn’s disease (CD) activity index (CDAI) in patients with CD. Methods: We measured fasting PFAA concentrations in 29 patients with CD and their correlation with disease activity. Results: In all patients, significant correlations were noted between CDAI and concentrations of valine, methionine, leucine, histidine, tryptophan, alanine, tyrosine, total amino acids (TAAs), nonessential amino acids (NEAAs), essential amino acids (EAAs), and branched-chain amino acids (BCAAs). In patients with the ileo-colonic type of CD, significant correlations were noted between CDAI and valine, histidine, tryptophan, glutamine, TAA, NEAA, EAA, and BCAA. In ileal type, significant correlations were observed between CDAI and threonine, valine, histidine, serine, and glycine. In colonic type, significant correlations were noted between CDAI and valine, histidine, tryptophan, TAA, NEAA, EAA, and BCAA. Conclusions: In patients with CD, plasma amino acids appear to be associated with disease activity.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Disease
Activity index
Free amino
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
In patient
lcsh:RC799-869
Original Research
chemistry.chemical_classification
Crohn's disease
030109 nutrition & dietetics
CDAI
business.industry
Crohn disease
medicine.disease
digestive system diseases
Amino acid
Crohn disease activity index
chemistry
Amino acids
lcsh:Diseases of the digestive system. Gastroenterology
030211 gastroenterology & hepatology
business
disease activity
Subjects
Details
- ISSN :
- 11795522
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Clinical Medicine Insights: Gastroenterology
- Accession number :
- edsair.doi.dedup.....4baf2889f27b46e6c9d917e9c160125a