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Second-line chemotherapy with docetaxel and carboplatin in paclitaxel and platinum-pretreated ovarian, fallopian tube, and peritoneal cancer
Second-line chemotherapy with docetaxel and carboplatin in paclitaxel and platinum-pretreated ovarian, fallopian tube, and peritoneal cancer
- Source :
- Medical Oncology. 29:1253-1254
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- We retrospectively evaluated the efficacy and toxicity of docetaxel and carboplatin in patients with platinum and paclitaxel-pretreated recurrent ovarian, fallopian tube, and peritoneal cancer. Forty-two women (38 with ovarian cancer, 1 with fallopian tube cancer, 3 with peritoneal cancer) whose cancer had progressed within 12 months of their last treatment with both a platinum agent and paclitaxel were treated with docetaxel (70 mg/m(2), day 1) and carboplatin (area under the curve of 4-6, day 1). Thirty-four patients had measurable disease. The objective response rate was 23% within 0-6 months of the progression-free interval, 50% within 6-12 months, and 32% (11 of 34 patients) for both groups. The median time to tumor progression was 28, 49, 34 weeks, and the median overall survival time was 94, 224, 111 weeks, respectively. The most common toxicity was grade 3/4 neutropenia (98% of patients), with 15 episodes (8.4% of courses) of neutropenic fever. The main nonhematologic toxicity was hypersensitivity; 7 patients (17%) required discontinuation of the therapy. The results of our study indicate that the combination of docetaxel and carboplatin is effective against recurrent ovarian, fallopian tube, and peritoneal cancer with progression-free interval of 6-12 months from previous treatment by paclitaxel and platinum. On the other hand, single-agent chemotherapy would be better than this regimen considering its low response rate and severe hematological toxicity for patients with progression-free interval less than 6 months.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Paclitaxel
medicine.medical_treatment
Docetaxel
Gastroenterology
Carboplatin
chemistry.chemical_compound
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Fallopian Tube Neoplasms
Humans
Peritoneal Neoplasms
Platinum
Retrospective Studies
Ovarian Neoplasms
Salvage Therapy
Chemotherapy
business.industry
Cancer
Hematology
General Medicine
medicine.disease
female genital diseases and pregnancy complications
Treatment Outcome
medicine.anatomical_structure
chemistry
Drug Resistance, Neoplasm
Fallopian tube cancer
Female
Taxoids
business
Ovarian cancer
Follow-Up Studies
Fallopian tube
medicine.drug
Subjects
Details
- ISSN :
- 1559131X and 13570560
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Medical Oncology
- Accession number :
- edsair.doi.dedup.....4bdc24cc2bead3b9717d00797ffa8cda
- Full Text :
- https://doi.org/10.1007/s12032-011-9878-z