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Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
- Source :
- Journal of Autism and Developmental Disorders
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD) = 0.97, 95% confidence interval (95% CI) = 0.41–1.53; p
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Autism Spectrum Disorder
Central nervous system
S100 Calcium Binding Protein beta Subunit
S100B
03 medical and health sciences
0302 clinical medicine
Internal medicine
Developmental and Educational Psychology
medicine
Humans
Child
030304 developmental biology
Original Paper
0303 health sciences
medicine.disease
Confidence interval
Peripheral blood
Meta-analysis
Blood
medicine.anatomical_structure
Autism spectrum disorder
Strictly standardized mean difference
Child, Preschool
Autism
Biomarker (medicine)
Female
Psychology
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15733432 and 01623257
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Journal of Autism and Developmental Disorders
- Accession number :
- edsair.doi.dedup.....4be4f0fd1dc4f371b621d6efc7386a18