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Application of nanotechnology in acute kidney injury: From diagnosis to therapeutic implications
- Source :
- Journal of Controlled Release. 336:233-251
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Acute kidney injury (AKI), a major health issue concerning ~50% of patients treated in intensive care units, generally leads to severe renal damage associated with high mortality rate. The application of nanotechnology for the management of AKI has profound potential of further development, providing innovative strategies for predicting the early onset and progression of renal disease and improving the treatment efficacy of the life-threating AKI. This review has comprehensively summarized the nanomedicines in the application of AKI diagnosis and emphatically discussed the unique potential of various nanotechnology-based drug delivery systems (e.g., polymeric nanoparticles, organic nanoparticles, inorganic nanoparticles, lipid-based nanoparticles, hydrogels etc.) in the treatment of AKI, allowing for improved therapeutic index by enhancing both efficacy and safety concurrently. These approaches may mechanically mitigate oxidative stress, inflammation, and mitochondrial and other organellar damage, etc. In addition, the combination of nanotechnology with stem cells-based therapy or gene therapy has been explored for reducing renal tissues damage and promoting kidney repair or recovery from AKI. The review provides insights into the synthesis, advantages, and limitations of innovative nanomedicine application in the early detection and effective treatment of AKI.
- Subjects :
- Genetic enhancement
Pharmaceutical Science
Nanotechnology
02 engineering and technology
Disease
Kidney
urologic and male genital diseases
03 medical and health sciences
Drug Delivery Systems
Therapeutic index
Intensive care
medicine
Humans
030304 developmental biology
0303 health sciences
business.industry
Acute kidney injury
Acute Kidney Injury
021001 nanoscience & nanotechnology
medicine.disease
female genital diseases and pregnancy complications
Nanomedicine
Drug delivery
Stem cell
0210 nano-technology
business
Subjects
Details
- ISSN :
- 01683659
- Volume :
- 336
- Database :
- OpenAIRE
- Journal :
- Journal of Controlled Release
- Accession number :
- edsair.doi.dedup.....4bf4e79e3fde16e1a32f31a56699f808