Swimming test for evaluating vestibular function in guinea pigs

A swimming test was used to evaluate vestibular function in guinea pigs. We first observed tracings of the swimming patterns of 20 healthy guinea pigs to establish the normal range. Then the same test was used in a group of 49 guinea pigs with endolymphatic hydrops induced by immunologic techniques. They did not show spontaneous nystagmus or body deviation while walking, but a total of 20 out of 49 animals displayed abnormal swimming patterns, with 8 swimming clockwise and 4 counterclockwise. This swimming test is easily able to detect mild vestibular dysfunction in guinea pigs, and can be repeated, so that we consider it useful for examining vestibular function in these animals.