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Fanconi syndrome with renal sodium wasting and metabolic alkalosis
- Source :
- The American Journal of Medicine. 44:638-646
- Publication Year :
- 1968
- Publisher :
- Elsevier BV, 1968.
-
Abstract
- A boy with idiopathic Fanconi's syndrome is described who exhibited, in addition to the usual features, an unusually large degree of urinary sodium chloride wastage accompanied by a metabolic alkalosis. No evidence of distal tubular abnormality was found and all urinary findings were explicable on the basis of proximal tubular malfunction. Investigations revealed that a combination of sodium, chloride and potassium depletion produced an alkalosis despite the presence of a low bicarbonate threshold commonly found in this syndrome. Detailed studies suggested that although potassium depletion may play a smaller role than sodium chloride wastage, its effects are real and in some degree mediated by an effect upon proximal tubular bicarbonate reabsorption.
- Subjects :
- Male
medicine.medical_specialty
Alkalosis
Metabolic Clearance Rate
Sodium
Bicarbonate
Metabolic alkalosis
chemistry.chemical_element
Diuresis
Sodium Chloride
Chloride
chemistry.chemical_compound
Internal medicine
medicine
Humans
Plasma Volume
Aldosterone
Acidosis
Acid-Base Equilibrium
business.industry
Fanconi syndrome
Acidosis, Renal Tubular
General Medicine
Hydrogen-Ion Concentration
Fanconi Syndrome
medicine.disease
Diet
Kidney Tubules
Endocrinology
chemistry
Child, Preschool
Potassium
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 00029343
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- The American Journal of Medicine
- Accession number :
- edsair.doi.dedup.....4c22073cf997546b487b62defb7fb46b
- Full Text :
- https://doi.org/10.1016/0002-9343(68)90066-1