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Simultaneous Enantiospecific Detection of Multiple Compounds in Mixtures using NMR Spectroscopy
- Source :
- Angewandte Chemie (International ed. in English). 59(52)
- Publication Year :
- 2020
-
Abstract
- Chirality plays a fundamental role in nature, but its detection and quantification still face many limitations. To date, the enantiospecific analysis of mixtures necessarily requires prior separation of the individual components. The simultaneous enantiospecific detection of multiple chiral molecules in a mixture represents a major challenge, which would lead to a significantly better understanding of the underlying biological processes; for example, via enantiospecifically analysing metabolites in their native environment. Here, we report on the first in situ enantiospecific detection of a thirty-nine-component mixture. As a proof of concept, eighteen essential amino acids at physiological concentrations were simultaneously enantiospecifically detected using NMR spectroscopy and a chiral solvating agent. This work represents a first step towards the simultaneous multicomponent enantiospecific analysis of complex mixtures, a capability that will have substantial impact on metabolism studies, metabolic phenotyping, chemical reaction monitoring, and many other fields where complex mixtures containing chiral molecules require efficient characterisation.
- Subjects :
- Magnetic Resonance Spectroscopy
Resolution (mass spectrometry)
SAMPLES
Chemistry, Multidisciplinary
multicomponent
010402 general chemistry
01 natural sciences
H-1-NMR
Catalysis
CHIRAL MOLECULES
NMR spectroscopy
Still face
simultaneous enantiospecific analysis
Enantiomeric excess
complex mixture
mixture effect
Science & Technology
COMPLEX
010405 organic chemistry
Chemistry
Organic Chemistry
H-1
Stereoisomerism
General Chemistry
Nuclear magnetic resonance spectroscopy
Combinatorial chemistry
0104 chemical sciences
DIFFERENTIATION
RESOLUTION
Physical Sciences
ACID
ENANTIOMERIC EXCESS
Chirality (chemistry)
D-SERINE
03 Chemical Sciences
Subjects
Details
- ISSN :
- 15213773
- Volume :
- 59
- Issue :
- 52
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie (International ed. in English)
- Accession number :
- edsair.doi.dedup.....4c280005108cd905cad1174141684b1e