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Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression
- Source :
- CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
- Publication Year :
- 2005
- Publisher :
- Oxford University Press, 2005.
-
Abstract
- In this paper we demonstrate, using the C7-2-HI metastatic transplantable ductal mammary tumor, that endocrine therapy can induce complete regression of spontaneous lymph node and lung metastases in a mouse model of breast cancer progression. This tumor expresses high levels of estrogen and progesterone receptors and shows a high incidence of early axillary lymph nodes and lung metastases; using this model we had previously shown complete tumor regression of subcutaneous implants. Interestingly, although the metastases showed a more differentiated histology as compared with the primary growth, they underwent complete regression when treated with estrogens or antiprogestins. This phenomenon was associated with sustained cytostasis and apoptosis accompanied by increases in p21 and p27 expression and early tissue remodeling. These results highlight the essential role of PR in regulating cell proliferation in this model as well as its possible use as therapeutic target. Fil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina Fil: Soldati, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Meiss, Roberto. Academia Nacional de Medicina de Buenos Aires; Argentina Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina Fil: Molinolo, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Public Health Service. National Institute Of Health; Estados Unidos Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
- Subjects :
- Cancer Research
Lung Neoplasms
Apoptosis
Cell Cycle Proteins
Metastasis
Mice
Lymph node
Mice, Inbred BALB C
Mammary tumor
Estradiol
Patología
General Medicine
purl.org/becyt/ford/3.1 [https]
Bioquímica y Biología Molecular
Mammary Carcinomas
Cytostasis
Medicina Básica
Mifepristone
medicine.anatomical_structure
Receptors, Estrogen
Antiprogestins
Lymphatic Metastasis
Female
purl.org/becyt/ford/3 [https]
Receptors, Progesterone
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinase Inhibitor p21
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Axillary lymph nodes
medicine.drug_class
Transplantation, Heterologous
Mitosis
Breast cancer
Internal medicine
medicine
Animals
business.industry
Tumor Suppressor Proteins
Mammary Neoplasms, Experimental
Estrogens
medicine.disease
Treatment
Endocrinology
Tumor progression
Estrogen
Cancer research
Progestins
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
- Accession number :
- edsair.doi.dedup.....4c54398f2e97712369031f10410551e4