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Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus–induced type 2 responses and immunopathology
- Source :
- Journal of Allergy and Clinical Immunology. 142:683-687.e12
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- GLP-1R signaling, an emerging anti-inflammatory therapeutic 59 target, 60 attenuated type 2-associated immunopathology in mice infected with a strain of RSV that was 61 isolated from a hospitalized infant with severe lower respiratory tract infection and bronchiolitis.
- Subjects :
- 0301 basic medicine
Immunology
Respiratory Syncytial Virus Infections
Lymphocyte Activation
Glucagon-Like Peptide-1 Receptor
Article
Virus
Mice
03 medical and health sciences
Th2 Cells
0302 clinical medicine
Immunity
Lower respiratory tract infection
Immunopathology
Animals
Humans
Hypoglycemic Agents
Immunology and Allergy
Medicine
Respiratory system
Cells, Cultured
Mice, Inbred BALB C
Interleukin-13
business.industry
Infant
Liraglutide
Viral Load
medicine.disease
Glucagon-like peptide-1
Immunity, Innate
Respiratory Syncytial Viruses
030104 developmental biology
Bronchiolitis
030220 oncology & carcinogenesis
Signal transduction
business
Signal Transduction
Subjects
Details
- ISSN :
- 00916749
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....4c5aceed2eb3df18e40b7aafb0db5fdb
- Full Text :
- https://doi.org/10.1016/j.jaci.2018.01.053