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Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus–induced type 2 responses and immunopathology

Authors :
Jian Zhang
Kasia Goleniewska
Matthew T. Stier
Kelli L. Boyd
R. Stokes Peebles
James D. Chappell
Kevin D. Niswender
Dawn C. Newcomb
Mark Rusznak
Lisa Bastarache
Tina V. Hartert
Connor C. Pfister
Melissa H. Bloodworth
Martin L. Moore
Weisong Zhou
Shinji Toki
Sandra Alvarez Calvillo
Source :
Journal of Allergy and Clinical Immunology. 142:683-687.e12
Publication Year :
2018
Publisher :
Elsevier BV, 2018.

Abstract

GLP-1R signaling, an emerging anti-inflammatory therapeutic 59 target, 60 attenuated type 2-associated immunopathology in mice infected with a strain of RSV that was 61 isolated from a hospitalized infant with severe lower respiratory tract infection and bronchiolitis.

Details

ISSN :
00916749
Volume :
142
Database :
OpenAIRE
Journal :
Journal of Allergy and Clinical Immunology
Accession number :
edsair.doi.dedup.....4c5aceed2eb3df18e40b7aafb0db5fdb
Full Text :
https://doi.org/10.1016/j.jaci.2018.01.053