TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion

The results of studies on the genetics of complex traits need to be replicated and to reach robust statistical significance before they can be considered as established. We here tried to replicate the previously reported association between the TRIB3 Q84R polymorphism (rs2295490) and glucose homeostasis. Three samples of Europeans with fasting glucose