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P121 ASSOCIATION OF CARDIORESPIRATORY FITNESS WITH ARTERIAL STIFFNESS AND PERIPHERAL AND CENTRAL BLOOD PRESSURE IN RESISTANT HYPERTENSION PATIENTS
- Source :
- Artery Research, Vol 24 (2018)
- Publication Year :
- 2018
- Publisher :
- Atlantis Press, 2018.
-
Abstract
- Background: The relationship between arterial stiffness, blood pressure (BP) and cardiorespiratory fitness (CRF) has been studied in healthy populations and cardiovascular patients, since all of which proved to be independent predictors of all-cause mortality. We aimed to investigate the association of CRF with arterial stiffness and peripheral and central hemodynamics, in patients with resistant hypertension (RT). Methods: In this cross-sectional study, 30 patients (13 men, 17 women; age, 57.7 ± 8.1 years; weight, 79.2 ± 11.6 kg; body mass index, 29.7 ± 4.0 kg/m2) with resistant hypertension were recruited in the Hospital Infante D. Pedro (Aveiro) and Hospital Pedro Hispano (Matosinhos). Outcome measures included CRF (VO2peak), peripheral and central BP, and carotid-femoral pulse wave velocity (cf-PWV). Correlation analysis was conducted to assess the association between variables. Results: A significant negative correlation was found between VO2peak (33.7 ± 6.2 mLO2/kg/min) and central (141.0±21.3 mmHg; r = −0.395, p = 0.031) and peripheral systolic BP (148.4 ± 21.3 mmHg; r = −0.363, p = 0.049). VO2peak was also correlated with pulse pressure (PP) amplification ratio (1.2 ± 0.1 mmHg; r = 0.361, p = 0.050). The association with central systolic BP (r = −0.403, p = 0.035) and PP amplification ratio (r = 0.408, p = 0.033) remained significant after adjusted for age. VO2peak showed no correlation with PWV (9.4 ± 2.9 m/s; r = −0.075, p = 0.694) and peripheral (88.1 ± 12.2 mmHg; r = −0.138 p = 0.467) and central diastolic BP (88.5 ± 12.7 mmHg; r = −0.133, p = 0.483). Conclusion: This study confirms the inverse relationship between CRF and central systolic BP and PP amplification ratio in RH patients, regardless of age.
- Subjects :
- medicine.medical_specialty
business.industry
Resistant hypertension
Specialties of internal medicine
Cardiorespiratory fitness
General Medicine
medicine.disease
Peripheral
Central blood pressure
RC581-951
Internal medicine
RC666-701
Arterial stiffness
Cardiology
Medicine
Diseases of the circulatory (Cardiovascular) system
business
Subjects
Details
- Language :
- English
- ISSN :
- 18764401
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Artery Research
- Accession number :
- edsair.doi.dedup.....4c7cdd9923efbd1b237fefbf9cee8e36