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Behavioral and electroencephalographic effects of Clozapine (W-801)
- Source :
- Folia Pharmacologica Japonica. 69:85-119
- Publication Year :
- 1973
- Publisher :
- Japanese Pharmacological Society, 1973.
-
Abstract
- The behavioral and electroencephalographic effects of Clozapine were investigated in mice, rats and rabbits, and compared with chlorpromazine and perphenazine. Clozapine showed in general the pharmacologic properties characteristic to neuroleptics, such as decrease in exploratory behavior, suppression of conditiond avoidance response, taming effects, anti-methamphetamine and so on. These effects were less potent and shoter in duration than those of chlorpromazine and perphenazine. Clozapine, however, lacked cataleptogenic propeties and depressed the EEG arousal responses induced not only by auditory but also by mesencephalic reticular stimulation, differently from chlorpromazine and perphenazine.
- Subjects :
- Male
Recruitment, Neurophysiological
Perphenazine
Reserpine
Chlorpromazine
Conditioning, Classical
Stimulation
Pharmacology
Avoidance response
Electroencephalography
Methamphetamine
Mice
Dibenzazepines
Mesencephalon
Avoidance Learning
Animals
Humans
Medicine
Clozapine
Cerebral Cortex
Behavior, Animal
Dose-Response Relationship, Drug
medicine.diagnostic_test
business.industry
Electric Stimulation
Rats
Aggression
Anesthesia
Exploratory Behavior
Rabbits
business
medicine.drug
Subjects
Details
- ISSN :
- 13478397 and 00155691
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Folia Pharmacologica Japonica
- Accession number :
- edsair.doi.dedup.....4c8fa7c300d91d47b67706c3f957e5f3