Back to Search
Start Over
Testicular immunoregulatory factors
- Source :
- Journal of reproductive immunology. 18(1)
- Publication Year :
- 1990
-
Abstract
- The present data indicate that immune cells are regulated locally in the testis by Leydig cells, Sertoli cells and resident testicular macrophages. The effects of these cells are mediated by several peptide factors, including protectin, a group of high molecular weight testicular immunosuppressive factors, and testicular interleukin-1 alpha-like factor. The testicular interleukin-1 alpha-like factor is produced by Sertoli cells and is under hypophyseal control. Its synthesis starts at puberty concomitantly with the onset of spermatogenesis and it may act as a spermatogonial growth factor. Protectin, which is under hypophyseal control, may be involved in the mechanism of prolonged transplant survival in the testicular interstitial tissue. Its levels increase at puberty. Both the testicular interleukin-1 alpha-like activity and protectin may be important in testicular pathophysiology.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
endocrine system diseases
medicine.medical_treatment
Immunology
Receptors, Cell Surface
Testicle
Biology
urologic and male genital diseases
Immune system
Internal medicine
Testis
medicine
Immune Tolerance
Suppressor Factors, Immunologic
Immunology and Allergy
Macrophage
Animals
Humans
Lymphocytes
Leydig cell
urogenital system
Growth factor
Obstetrics and Gynecology
Interleukin
Sertoli cell
medicine.anatomical_structure
Endocrinology
Reproductive Medicine
Peptides
Spermatogenesis
Interleukin-1
Subjects
Details
- ISSN :
- 01650378
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of reproductive immunology
- Accession number :
- edsair.doi.dedup.....4cc3bb3f7febc019b8d91155b4ea95cd