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Recent advances in orally administered cell-specific nanotherapeutics for inflammatory bowel disease
- Source :
- World Journal of Gastroenterology
- Publication Year :
- 2016
- Publisher :
- Baishideng Publishing Group Inc., 2016.
-
Abstract
- Inflammatory bowel disease (IBD) is a chronic relapsing disease in gastrointestinal tract. Conventional medications lack the efficacy to offer complete remission in IBD therapy, and usually associate with serious side effects. Recent studies indicated that nanoparticle-based nanotherapeutics may offer precise and safe alternative to conventional medications via enhanced targeting, sustained drug release, and decreased adverse effects. Here, we reviewed orally cell-specific nanotherapeutics developed in recent years. In addition, the various obstacles for oral drug delivery are also reviewed in this manuscript. Orally administrated cell-specific nanotherapeutics is expected to become a novel therapeutic approach for IBD treatment.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Administration, Oral
Fusion Regulatory Protein-1
Endosomes
Review
02 engineering and technology
Disease
Gastroenterology
Inflammatory bowel disease
Epithelium
Permeability
03 medical and health sciences
Therapeutic approach
Nanotherapeutic
Oral administration
Internal medicine
Receptors, Transferrin
medicine
Animals
Humans
Hyaluronic Acid
Adverse effect
Cell Nucleus
Cell specific
Drug Carriers
Gastrointestinal tract
business.industry
Galactose
Hydrogels
General Medicine
Hydrogen-Ion Concentration
Inflammatory Bowel Diseases
021001 nanoscience & nanotechnology
medicine.disease
Gastrointestinal Tract
Cell-specificity
030104 developmental biology
Pharmaceutical Preparations
Nanoparticles
Reactive Oxygen Species
0210 nano-technology
business
Mannose
Oral retinoid
Subjects
Details
- ISSN :
- 10079327
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....4ccdc3390e81f6d4523dbe108e252009