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Bias in comparisons of mortality among very preterm births: A cohort study
- Source :
- PLoS ONE, Vol 16, Iss 6, p e0253931 (2021), PLoS ONE
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Background Several studies of prenatal determinants and neonatal morbidity and mortality among very preterm births have resulted in unexpected and paradoxical findings. We aimed to compare perinatal death rates among cohorts of very preterm births (24–31 weeks) with rates among all births in these groups (≥24 weeks), using births-based and fetuses-at-risk formulations. Methods We conducted a cohort study of singleton live births and stillbirths ≥24 weeks’ gestation using population-based data from the United States and Canada (2006–2015). We contrasted rates of perinatal death between women with or without hypertensive disorders, between maternal races, and between births in Canada vs the United States. Results Births-based perinatal death rates at 24–31 weeks were lower among hypertensive than among non-hypertensive women (rate ratio [RR] 0.67, 95% CI 0.65–0.68), among Black mothers compared with White mothers (RR 0.94, 95%CI 0.92–0.95) and among births in the United States compared with Canada (RR 0.74, 95%CI 0.71–0.75). However, overall (≥24 weeks) perinatal death rates were higher among births to hypertensive vs non-hypertensive women (RR 2.14, 95%CI 2.10–2.17), Black vs White mothers (RR 1.86, 95%CI 184–1.88;) and births in the United States vs Canada (RR 1.08, 95%CI 1.05–1.10), as were perinatal death rates based on fetuses-at-risk at 24–31 weeks (RR for hypertensive disorders: 2.58, 95%CI 2.53–2.63; RR for Black vs White ethnicity: 2.29, 95%CI 2.25–2.32; RR for United States vs Canada: 1.27, 95%CI 1.22–1.30). Conclusion Studies of prenatal risk factors and between-centre or between-country comparisons of perinatal mortality bias causal inferences when restricted to truncated cohorts of very preterm births.
- Subjects :
- Maternal Health
Ethnic group
Blood Pressure
Rate ratio
Vascular Medicine
Cohort Studies
Labor and Delivery
0302 clinical medicine
Pregnancy
Medicine and Health Sciences
Medicine
030212 general & internal medicine
Birth Rate
education.field_of_study
Multidisciplinary
Obstetrics
Perinatal mortality
Mortality rate
Obstetrics and Gynecology
3. Good health
Very preterm
Hypertension
Premature Birth
Gestation
Female
Stillbirths
Research Article
Cohort study
Adult
Canada
medicine.medical_specialty
Death Rates
Science
Population
Preterm Birth
03 medical and health sciences
Population Metrics
Bias
Hypertensive Disorders in Pregnancy
030225 pediatrics
Humans
education
Fetal Death
Population Biology
business.industry
Racial Groups
Infant, Newborn
Biology and Life Sciences
Neonates
Hypertension, Pregnancy-Induced
United States
Pregnancy Complications
Birth
Women's Health
business
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....4cea9d438f7245903066383e7f1d30d9