Xylan-based hydrogels for potential skin care application

Skin care biomaterials from natural compounds are increasingly needed in recent. We demonstrate a simple strategy to fabricate the dialdehyde xylan (DAX) crosslinked hydrogel with skin care potential. The hydrogel mainly consists of dialdehyde xylan, which is used as crosslinker for gelatin (G). Glycerol (Gly) and nicotinamide (NCA) are introduced here for improving the texture, antibacterial property as well as skin care functionality. The in vitro release results demonstrate that NCA can be released smoothly from the xylan-based gel, whereby the xylan-based fabricated gel can be utilized as an ideal matrix gel in skin care with loading and release function. The antibacterial ability is in the following order: Yeast > Bacillus subtilis > Staphylococcus aureus. The cytocompatibility experiments confirm the excellent viability of the gel. These merits demonstrate the fabricated hydrogel as a potential material in skin care.